Document Detail

Atypical Fibrous Histiocytoma Arising in the Perianal Area: A Case Report and Review of the Literature.
MedLine Citation:
PMID:  24061404     Owner:  NLM     Status:  Publisher    
: Atypical fibrous histiocytoma (AFH) is an uncommon variant of cutaneous fibrous histiocytoma that can display histologic features associated with malignancy. Fewer than 150 cases have been reported in the literature. The majority of these lesions present on the trunk and extremities of middle-aged women. Genital lesions are rare, with one documented case of vulvar AFH and another case of scrotal AFH in the literature. We report an additional case of a 68-year-old woman who was diagnosed with an AFH in an unusual location, the perianal area. Histologically, the lesion was characterized by a nodular fairly well-circumscribed proliferation of large epithelioid macrophages with scattered lymphocytes and mast cells in the background. The atypical macrophages contained enlarged markedly pleomorphic nuclei with prominent nucleoli. Scattered multinucleated "monster cells" and atypical mitoses were observed throughout the lesion. Immunologically, the lesional cells were focally positive when stained with antibodies against CD163 and Factor XIIIa. They were negative for CD34, CD31, desmin, smooth muscle actin, CAM 5.2, keratin 5/6, S100, CD3, CD20, and CD30. The constellation of histologic and immunologic features was most consistent with an AFH. To our knowledge, this case is the first perianal presentation of AFH to date.
Yen Tun Wang; Chandra N Smart
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-9-20
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  -     ISSN:  1533-0311     ISO Abbreviation:  Am J Dermatopathol     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-9-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
*Division of Dermatology and †Department of Pathology and Laboratory Medicine, Ronald Reagan UCLA Medical Center, Los Angeles, CA.
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