Document Detail


Atypical corneal immunoglobulin deposition in a patient with dysproteinemia.
MedLine Citation:
PMID:  19907308     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The purpose of this study was to report an unusual pattern of immunoglobulin deposition in the corneas of a patient with dysproteinemia.
METHODS: Clinical examination, slit lamp examination, a deep lamellar corneal biopsy, and serum and aqueous protein electrophoresis were obtained.
RESULTS: Slit lamp evaluation revealed amorphous, cloud-like opacities in the midperiphery at the level of deep stroma and Descemet's membrane. Electron microscopy demonstrated deep lamellar extracellular deposits consistent with immunoglobin. The serum protein electrophoresis revealed a monoclonal IgG kappa band, but the aqueous electrophoresis showed no bands in the gamma region.
CONCLUSION: This case documents a rare pattern of immunoglobulin deposition in the corneas in a patient with gammopathy. Despite its deep corneal distribution, the analysis of the aqueous specimen suggests that the source of the immunoglobulin is through a route other than from the aqueous.
Authors:
Alice Y Matoba; Patricia Chevez-Barrios; Dan B Jones
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cornea     Volume:  29     ISSN:  1536-4798     ISO Abbreviation:  Cornea     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-24     Completed Date:  2010-02-05     Revised Date:  2011-01-20    
Medline Journal Info:
Nlm Unique ID:  8216186     Medline TA:  Cornea     Country:  United States    
Other Details:
Languages:  eng     Pagination:  105-7     Citation Subset:  IM    
Affiliation:
Cullen Eye Institute, Baylor College of Medicine, Department of Ophthalmology, Houston, TX 77030, USA. amatoba@bcm.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Corneal Opacity / diagnosis,  metabolism*
Corneal Stroma / pathology*
Female
Humans
Immunoglobulin G / metabolism*
Immunoglobulin kappa-Chains / blood
Lymphoma, B-Cell / pathology
Paraproteinemias / diagnosis,  metabolism*
Visual Acuity / physiology
Grant Support
ID/Acronym/Agency:
EY02520/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Immunoglobulin G; 0/Immunoglobulin kappa-Chains
Comments/Corrections
Comment In:
Cornea. 2011 Feb;30(2):247; author reply 247-8   [PMID:  21099423 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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