| Atypical BH3-domains of BNIP3 and BNIP3L lead to autophagy in hypoxia. | |
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MedLine Citation:
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PMID: 19587545 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Normal and tumor cells subjected to a hypoxic microenvironment show evidence of autophagy. We hypothesize that cells will sense hypoxia as a warning signal to upcoming drastic microenvironmental conditions and that autophagy, acting as a survival mechanism, will provide time for cells to adapt. This work demonstrates for the first time that the atypical BH3-domain of BNIP3 and BNIP3L, two HIF-target genes, can compete with Beclin 1-Bcl-2 and Beclin 1-Bcl-X(L) complexes, releasing Beclin 1 from the complex and then enhancing autophagy. We thus revealed a new role for BH3-only proteins in the cellular response to hypoxia. |
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Authors:
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Nathalie M Mazure; Jacques Pouyss??gur |
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Publication Detail:
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Type: Journal Article Date: 2009-08-18 |
Journal Detail:
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Title: Autophagy Volume: 5 ISSN: 1554-8635 ISO Abbreviation: Autophagy Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-08-04 Completed Date: 2010-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101265188 Medline TA: Autophagy Country: United States |
Other Details:
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Languages: eng Pagination: 868-9 Citation Subset: IM |
Affiliation:
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Institute of Developmental Biology and Cancer, CNRS, Nice, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Autophagy* Cell Hypoxia Humans Membrane Proteins / chemistry*, metabolism* Models, Biological Protein Structure, Tertiary Proto-Oncogene Proteins / chemistry*, metabolism* Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Membrane Proteins; 0/Proto-Oncogene Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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