Document Detail

Atypical BH3-domains of BNIP3 and BNIP3L lead to autophagy in hypoxia.
MedLine Citation:
PMID:  19587545     Owner:  NLM     Status:  MEDLINE    
Normal and tumor cells subjected to a hypoxic microenvironment show evidence of autophagy. We hypothesize that cells will sense hypoxia as a warning signal to upcoming drastic microenvironmental conditions and that autophagy, acting as a survival mechanism, will provide time for cells to adapt. This work demonstrates for the first time that the atypical BH3-domain of BNIP3 and BNIP3L, two HIF-target genes, can compete with Beclin 1-Bcl-2 and Beclin 1-Bcl-X(L) complexes, releasing Beclin 1 from the complex and then enhancing autophagy. We thus revealed a new role for BH3-only proteins in the cellular response to hypoxia.
Nathalie M Mazure; Jacques Pouyss??gur
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Publication Detail:
Type:  Journal Article     Date:  2009-08-18
Journal Detail:
Title:  Autophagy     Volume:  5     ISSN:  1554-8635     ISO Abbreviation:  Autophagy     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-04     Completed Date:  2010-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101265188     Medline TA:  Autophagy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  868-9     Citation Subset:  IM    
Institute of Developmental Biology and Cancer, CNRS, Nice, France.
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MeSH Terms
Cell Hypoxia
Membrane Proteins / chemistry*,  metabolism*
Models, Biological
Protein Structure, Tertiary
Proto-Oncogene Proteins / chemistry*,  metabolism*
Structure-Activity Relationship
Reg. No./Substance:
0/Membrane Proteins; 0/Proto-Oncogene Proteins

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