Document Detail


Atypical BH3-domains of BNIP3 and BNIP3L lead to autophagy in hypoxia.
MedLine Citation:
PMID:  19587545     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Normal and tumor cells subjected to a hypoxic microenvironment show evidence of autophagy. We hypothesize that cells will sense hypoxia as a warning signal to upcoming drastic microenvironmental conditions and that autophagy, acting as a survival mechanism, will provide time for cells to adapt. This work demonstrates for the first time that the atypical BH3-domain of BNIP3 and BNIP3L, two HIF-target genes, can compete with Beclin 1-Bcl-2 and Beclin 1-Bcl-X(L) complexes, releasing Beclin 1 from the complex and then enhancing autophagy. We thus revealed a new role for BH3-only proteins in the cellular response to hypoxia.
Authors:
Nathalie M Mazure; Jacques Pouyss??gur
Related Documents :
6781425 - Improved oxygen delivery to the myocardium during hypothermia by perfusion with 2,3 dpg...
25346405 - Short- and long-term exposure to alternating magnetic field (50 hz, 0.5 mt) affects rat...
19587545 - Atypical bh3-domains of bnip3 and bnip3l lead to autophagy in hypoxia.
10974555 - Nadph oxidase subunit, gp91(phox) homologue, preferentially expressed in human colon ep...
2721585 - Growth-stimulating effect of transferrin on a hybridoma cell line: relation to transfer...
15248485 - Efficacies of plant phenolic compounds on sodium butyrate induced anti-tumour activity.
Publication Detail:
Type:  Journal Article     Date:  2009-08-18
Journal Detail:
Title:  Autophagy     Volume:  5     ISSN:  1554-8635     ISO Abbreviation:  Autophagy     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-04     Completed Date:  2010-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101265188     Medline TA:  Autophagy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  868-9     Citation Subset:  IM    
Affiliation:
Institute of Developmental Biology and Cancer, CNRS, Nice, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Autophagy*
Cell Hypoxia
Humans
Membrane Proteins / chemistry*,  metabolism*
Models, Biological
Protein Structure, Tertiary
Proto-Oncogene Proteins / chemistry*,  metabolism*
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Membrane Proteins; 0/Proto-Oncogene Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Measuring public health officers' opinions on new vaccination programs by means of the WHO Vaccine I...
Next Document:  Fear of commitment: Hes1 protects quiescent fibroblasts from irreversible cellular fates.