Document Detail

Atubular glomeruli in a rat model of polycystic kidney disease.
MedLine Citation:
PMID:  12427119     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Autosomal-dominant polycystic kidney disease (ADPKD) is associated with a progressive decline in glomerular filtration rate (GFR) that often leads to end-stage renal disease. The basis for this decline in GFR is poorly understood. METHODS: Glomeruli in heterozygous Han:SPRD rats with ADPKD and their normal litter mates were studied by light microscopy, using serial sectioning techniques. The connections of the renal corpuscles to proximal tubules were classified as normal, atrophied, or absent (atubular glomerulus). Renal corpuscles also were examined by scanning electron microscopy. Single nephron glomerular blood flows were determined using microspheres. RESULTS: In the kidneys of six-month-old rats with ADPKD, 50% of the glomeruli were atubular and another 26% were associated with atrophied neck segments; these glomeruli were most often smaller in size than normal. About 16% of the glomeruli were hypertrophied and had normal connections to proximal tubules. Sclerotic changes in cystic kidney glomeruli were usually mild or moderate, and belied the failure of glomerular function. Glomerular blood flow in the cystic kidneys averaged half of normal and was markedly heterogeneous; the majority of small glomeruli displayed very low blood flows and a few showed relatively high blood flows. Fewer glomerular abnormalities were found in rats treated for five months with potassium citrate in their drinking water. CONCLUSIONS: The diminished GFR in the rat with ADPKD can be accounted for largely by the formation of atubular glomeruli. Compensatory glomerular hypertrophy also is present and may contribute to the progression of the renal disease.
George A Tanner; Marcus A Tielker; Bret A Connors; Carrie L Phillips; Judith A Tanner; Andrew P Evan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Kidney international     Volume:  62     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-11-12     Completed Date:  2003-05-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1947-57     Citation Subset:  IM    
Department of Cellular and Integrative Physiology, Indiana UniversitySchool of Medicine, Indianapolis, Indiana, USA.
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MeSH Terms
Disease Models, Animal
Glomerular Filtration Rate
Kidney Glomerulus / pathology*,  ultrastructure
Kidney Tubules, Proximal / pathology*,  ultrastructure
Microscopy, Electron, Scanning
Polycystic Kidney Diseases / pathology*
Rats, Mutant Strains
Rats, Sprague-Dawley

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