| Attributes of Stachybotrys chartarum and its association with human disease. | |
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MedLine Citation:
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PMID: 14767429 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mold contamination and toxicities are not limited to crops and animals; they are also a concern in human health. Molds occur in outdoor and indoor environments, and water-damaged buildings harbor and provide substrate for several mold species. Of these, Stachybotrys chartarum poses a particular threat to occupants. Patients with building-related symptoms and infant idiopathic pulmonary hemorrhage often have histories of living in moldy, water-damaged buildings. Although a causal connection is far from being unequivocally proven, S. chartarum has been associated with such clinical conditions. These illnesses could be attributed in part to mycotoxins released by S. chartarum. Recently, a hemolysin released by this mold was found to be hemolytic in vitro and in vivo. In addition, allergenic proteins have been characterized from S. chartarum. The exact mechanism of S. chartarum pathogenesis has not yet been defined. Moreover, a causality-effect relation is not yet established. This review summarizes available information on the pathogenic attributes of S. chartarum and calls for well-controlled objective studies. |
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Authors:
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Mohammad Ashraf Hossain; Mohamed Sotohy Ahmed; Mahmoud Afif Ghannoum |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Journal of allergy and clinical immunology Volume: 113 ISSN: 0091-6749 ISO Abbreviation: J. Allergy Clin. Immunol. Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-02-09 Completed Date: 2004-03-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 200-8; quiz 209 Citation Subset: AIM; IM |
Affiliation:
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Center for Medical Mycology, University Hospitals of Cleveland, 11100 Euclid Ave, Cleveland, OH 44106-5028, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Environmental Exposure Hemolysin Proteins / metabolism* Hemorrhage / microbiology, physiopathology Hemosiderosis / microbiology, physiopathology Horse Diseases / microbiology Horses Humans Lung Diseases, Fungal / microbiology, physiopathology Mice Mice, Inbred BALB C Mycoses / microbiology, physiopathology* Mycotoxins / metabolism*, toxicity Stachybotrys / metabolism*, pathogenicity* |
| Chemical | |
Reg. No./Substance:
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0/Hemolysin Proteins; 0/Mycotoxins; 12698-94-1/stachybotrotoxin |
| Comments/Corrections | |
Comment In:
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J Allergy Clin Immunol. 2004 Jul;114(1):207; author reply 207-8
[PMID:
15282942
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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