Document Detail


Attributes of Stachybotrys chartarum and its association with human disease.
MedLine Citation:
PMID:  14767429     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mold contamination and toxicities are not limited to crops and animals; they are also a concern in human health. Molds occur in outdoor and indoor environments, and water-damaged buildings harbor and provide substrate for several mold species. Of these, Stachybotrys chartarum poses a particular threat to occupants. Patients with building-related symptoms and infant idiopathic pulmonary hemorrhage often have histories of living in moldy, water-damaged buildings. Although a causal connection is far from being unequivocally proven, S. chartarum has been associated with such clinical conditions. These illnesses could be attributed in part to mycotoxins released by S. chartarum. Recently, a hemolysin released by this mold was found to be hemolytic in vitro and in vivo. In addition, allergenic proteins have been characterized from S. chartarum. The exact mechanism of S. chartarum pathogenesis has not yet been defined. Moreover, a causality-effect relation is not yet established. This review summarizes available information on the pathogenic attributes of S. chartarum and calls for well-controlled objective studies.
Authors:
Mohammad Ashraf Hossain; Mohamed Sotohy Ahmed; Mahmoud Afif Ghannoum
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  113     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-09     Completed Date:  2004-03-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  200-8; quiz 209     Citation Subset:  AIM; IM    
Affiliation:
Center for Medical Mycology, University Hospitals of Cleveland, 11100 Euclid Ave, Cleveland, OH 44106-5028, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Environmental Exposure
Hemolysin Proteins / metabolism*
Hemorrhage / microbiology,  physiopathology
Hemosiderosis / microbiology,  physiopathology
Horse Diseases / microbiology
Horses
Humans
Lung Diseases, Fungal / microbiology,  physiopathology
Mice
Mice, Inbred BALB C
Mycoses / microbiology,  physiopathology*
Mycotoxins / metabolism*,  toxicity
Stachybotrys / metabolism*,  pathogenicity*
Chemical
Reg. No./Substance:
0/Hemolysin Proteins; 0/Mycotoxins; 12698-94-1/stachybotrotoxin
Comments/Corrections
Comment In:
J Allergy Clin Immunol. 2004 Jul;114(1):207; author reply 207-8   [PMID:  15282942 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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