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Attenuation of tissue oxidative stress by dietary restriction in rats on simulated microgravity.
MedLine Citation:
PMID:  22585609     Owner:  NLM     Status:  In-Data-Review    
Introduction Physiologic alterations caused by oxidative stress can be assessed by measuring tissue malondialdehyde (MDA) levels, a biomarker for oxidative stress. The goal of this study is to determine the consequences of a twenty percent caloric restriction on the increased oxidative stress documented in tissues from rats exposed to simulated microgravity. Materials/Methods Three groups of male SD rats (N=6 in each group) were used: Group 1, control; Group 2, food restricted (20% less food than control); and Group 3, food restricted with HLS. Group 3 was suspended after one week on the HLS-restricted diet and maintained for 14 days. Tissues harvested on day 14 were measured for MDA levels. Results The body weight gain of Group 2 and Group 3 was reduced as compared to that of Group 1 ( p <0.05) with no significant changes in water intakes. MDA levels in Group 2 were not different from those of the control group and were elevated only in liver tissues (p<0.05). In Group 3, MDA levels in the heart, liver, brain, and testes were significantly elevated (p<0.05) compared to the levels of Groups 1 and 2. Conclusions Food restriction alleviated tissue oxidative response in all tissues except for the liver. Excessive stress resulting from HLS appeared to have been minimized by dietary restriction in all tissues except for the heart, liver, brain, and testes.
John Jayroe; Michael Soulsby; Parimal Chowdhury
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of clinical and laboratory science     Volume:  42     ISSN:  1550-8080     ISO Abbreviation:  Ann. Clin. Lab. Sci.     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0410247     Medline TA:  Ann Clin Lab Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  140-4     Citation Subset:  IM    
PhD.; College of Medicine; University of Arkansas for Medical Sciences, Department of Physiology and Biophysics, 4301 W Markham Street, Little Rock, AR 72205; phone: (501) 686-5443; fax: (501) 686-8167; e-mail:
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