| Attenuation of proinflammatory cytokines and apoptotic process by verapamil and diltiazem against quinolinic acid induced Huntington like alterations in rats. | |
| | |
MedLine Citation:
|
PMID: 21112316 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Huntington disease is a neurodegenerative disease with complex pathophysiology. Recently, role of neuroinflammation and interplay between various other cellular cascades have been suggested to be involved in pathophysiology of Huntington disease. Involvement of calcium overload mediated oxidative damage and excitotoxicity have been suggested to play a central role in quinolinic acid induced Huntington like symptoms. The present study has been carried out to investigate the neuroprotective effect of calcium channel blockers (verapamil and diltiazem) against quinolinic acid induced dysfunction in motor, biochemical and neuroinflammatory signaling in rats. Intrastriatal quinolinic acid administration leads to significant motor [locomotor (72% reduction), rotarod (55% reduction), balance beam walk performance] dysfunction coupled with the marked oxidative damage and increased neuroinflammatory markers [TNF-α (140%), IL-6 (115%), caspase-3(75%)] levels in striatum as compared to the sham treatment. Verapamil (10 and 20mg/kg), diltiazem (10 and 20mg/kg) drug treatment for 21days resulted in a significant improvement in the motor function (improvement in locomotor activity, rotarod and balance beam walk performance). Further, verapamil (10 and 20mg/kg), diltiazem (10 and 20mg/kg) treatment significantly attenuated oxidative damage, level of proinflammatory mediators (TNF-α IL-6 and caspase-3) in quinolinic acid treated animals. Results of the present study demonstrate that protective effect of these calcium channel blockers (verapamil, diltiazem) might be due to their inhibitory action on different neuroinflammatory pathways against quinolinic acid induced Huntington disease like symptoms in rats. |
| | |
Authors:
|
Harikesh Kalonia; Puneet Kumar; Anil Kumar |
Related Documents
:
|
65186 - The different electrophoretic forms of post gamma-globulin their antigenic identity and... 2869456 - Effects of amino acid neurotransmitter candidates on an identified insect motoneurone. 17502686 - The properties of gelatin-poly (gamma-glutamic acid) hydrogels as biological glues. 15704886 - Templating photodimerization of trans-cinnamic acids with cucurbit[8]uril and gamma-cyc... 7439806 - Protective effects of cholestyramine on liver cirrhosis induced by carbon tetrachloride... 17629716 - Question 1: the fes/h2s system as a possible primordial source of redox energy. |
Publication Detail:
|
Type: Journal Article Date: 2010-11-26 |
Journal Detail:
|
Title: Brain research Volume: 1372 ISSN: 1872-6240 ISO Abbreviation: Brain Res. Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-01-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 115-26 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier B.V. All rights reserved. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Isotopomer enrichment assay for very short chain fatty acids and its metabolic applications.
Next Document: Atorvastatin and pitavastatin improve cognitive function and reduce senile plaque and phosphorylated...