Document Detail

Attenuation of muscle metaboreflex in chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  18091025     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Abnormal skeletal muscle function is well documented in chronic obstructive pulmonary disease, but there is no information about the activity of muscle metabosensitive afferents. In this study, we tested the hypothesis that patients with chronic obstructive pulmonary disease would have abnormal reflex responses to stimulation of metabosensitive afferents in skeletal muscle when compared with healthy, matched subjects. METHODS: In 16 patients with moderate to severe chronic obstructive pulmonary disease and 13 healthy, age-matched control subjects, we evaluated heart rate, mean blood pressure, calf blood flow, and calf vascular resistance responses to static handgrip exercise at 30% of maximal voluntary contraction, followed by recovery with or without circulatory occlusion. Muscle metaboreflex control of calf vascular resistance was estimated by subtracting the area under the curve with circulatory occlusion from the area under the curve without circulatory occlusion. RESULTS: Mean blood pressure and heart rate responses were not significantly different in patients and controls during exercise and recovery. In the control group, calf vascular resistance increased significantly during exercise and remained elevated above baseline during circulatory occlusion, whereas in patients changes from rest were not significantly different in both trials. Estimated muscle metaboreflex control of calf vascular resistance was significantly reduced in the patients (controls: 31 +/- 22 units, patients: 8 +/- 31 units, P < 0.05). CONCLUSION: Patients with chronic obstructive pulmonary disease have a reduced calf vascular resistance response to handgrip exercise and to selective activation of muscle metaboreflex when compared with healthy subjects.
Bruno T Roseguini; Cristiano N Alves; Gaspar R Chiappa; Ricardo Stein; Marli M Knorst; Jorge P Ribeiro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  40     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-09     Completed Date:  2008-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9-14     Citation Subset:  IM; S    
Exercise Pathophysiology Research Laboratory, Hospital of Clinics of Porto Alegre, Porto Alegre, Brazil.
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MeSH Terms
Blood Pressure
Case-Control Studies
Exercise Test
Heart Rate
Leg / blood supply*
Metabolic Diseases / physiopathology*
Middle Aged
Pulmonary Disease, Chronic Obstructive / physiopathology*
Respiratory Function Tests
Sickness Impact Profile

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