Document Detail


Attenuation of ischaemia-induced regional myocardial acidosis by bevantolol, a beta 1-adrenoceptor antagonist, in dogs.
MedLine Citation:
PMID:  2568629     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In dogs anaesthetized with pentobarbital, the left anterior descending coronary artery (LAD) was occluded for 90 min. so that about 1/2 of the original flow was allowed to flow (partial occlusion). Bevantolol (a beta 1-adrenoceptor antagonist) or propranolol (a reference drug) was injected intravenously 30 min. after partial occlusion. Regional myocardial pH was measured by a micro glass pH electrode inserted in the LAD area. Partial occlusion decreased myocardial pH by 0.62 to 0.74. Bevantolol (1.0 mg/kg) or propranolol (1.0 mg/kg) significantly increased myocardial pH, that had been decreased by partial occlusion, within 60 min. after the injection. Restoration of myocardial [H+] (defined as return towards a lower [H+] to the preocclusion level) (calculated from the pH data) induced by bevantolol and that induced by propranolol were 64.0 and 66.4% (measured 60 min. after the injection), respectively. Bevantolol or propranolol decreased heart rate also. Even in the paced heart, bevantolol restored the myocardial [H+] that had been increased by partial occlusion. These results suggest that bevantolol has a favorable effect on the ischaemic myocardium as has propranolol, and that the pH effect of bevantolol is not primarily due to a decrease in heart rate.
Authors:
T Hino; K Sakai; K Ichihara; Y Abiko
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology & toxicology     Volume:  64     ISSN:  0901-9928     ISO Abbreviation:  Pharmacol. Toxicol.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-08-15     Completed Date:  1989-08-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8702180     Medline TA:  Pharmacol Toxicol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  324-8     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Asahikawa Medical College, Japan.
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MeSH Terms
Descriptor/Qualifier:
Acidosis / metabolism,  prevention & control*
Adrenergic beta-Antagonists / pharmacology*
Animals
Blood Pressure / drug effects
Coronary Disease / metabolism*
Coronary Vessels / physiology
Dogs
Female
Heart Rate / drug effects
Hydrogen-Ion Concentration
Male
Myocardium / metabolism
Propanolamines / pharmacology*
Propranolol / pharmacology
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Propanolamines; 525-66-6/Propranolol; 59170-23-9/bevantolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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