Document Detail

Attenuation of hypotension using phenylephrine during induction of anaesthesia with propofol.
MedLine Citation:
PMID:  18062519     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To observe if phenylephrine mixed with propofol can attenuate hypotensive effects of propofol during induction of anaesthesia. METHODS: A total number of 135 adult ASA-I and ASA-II patients were divided into three groups. (Group A, B and C). All patients were induced with propofol 2.5 mg per kg. In Group A (control group) patients received propofol mixed with 2cc of 0.9% normal saline. Group B (study group) patients received propofol mixed with 2cc of a solution containing phenylephrine 25 microg/cc (total 50 microg); Group C (study group) patients received propofol mixed with 2cc of a solution containing phenylephrine 50 microg/cc (total 100 microg). Haemodynamic variables like systolic, diastolic, mean arterial blood pressure and heart rate were noted. Hypotension was defined as 20% decrease in baseline systolic blood pressure recorded before induction of anaesthesia. RESULTS: Phenylephrine in a dose of 100 micrograms attenuated the drop in systolic blood pressure. However phenylephrine in a dose 50 micrograms did not effectively prevent anticipated drop in SBP. CONCLUSION: Phenylephrine in doses of 100 micrograms effectively attenuates anticipated hypotension upon induction of general anaesthesia with propofol.
Muhammad Imran; Fazal Hameed Khan; Mansoor Ahmed Khan
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  JPMA. The Journal of the Pakistan Medical Association     Volume:  57     ISSN:  0030-9982     ISO Abbreviation:  J Pak Med Assoc     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-12-07     Completed Date:  2008-01-08     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  7501162     Medline TA:  J Pak Med Assoc     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  543-7     Citation Subset:  IM    
Department of Anaesthesia, Aga Khan University, Karachi.
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MeSH Terms
Anesthetics, Intravenous / pharmacology,  therapeutic use*
Cardiotonic Agents / pharmacology,  therapeutic use*
Hypotension / diagnosis,  etiology,  prevention & control*
Middle Aged
Phenylephrine / pharmacology,  therapeutic use*
Propofol / pharmacology,  therapeutic use*
Risk Factors
Reg. No./Substance:
0/Anesthetics, Intravenous; 0/Cardiotonic Agents; 2078-54-8/Propofol; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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