Document Detail

Attenuation of hypercortisolemia in fawn-hooded rats by antidepressant drugs.
MedLine Citation:
PMID:  8405126     Owner:  NLM     Status:  MEDLINE    
Long-term (21 days) treatment with imipramine, clomipramine (tricyclic antidepressants) and clorgyline (monoamine-oxidase type A inhibiting antidepressant) produced significant decreases in plasma corticosterone levels in fawn-hooded (FH) rats. In contrast, plasma adrenocorticotropic hormone (ACTH) levels were not altered by chronic imipramine or clorgyline treatment but were significantly higher in chronic clomipramine-treated FH rats. These findings demonstrate a differential effect of chronic antidepressant treatment on plasma ACTH and corticosterone concentrations in FH rats and, furthermore, support the results of earlier studies suggesting that the FH rat strain may represent a genetic model of depression.
C S Aulakh; J L Hill; D L Murphy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  240     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-11-02     Completed Date:  1993-11-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  85-8     Citation Subset:  IM    
Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD 20892.
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MeSH Terms
Adrenocorticotropic Hormone / blood*
Analysis of Variance
Antidepressive Agents / pharmacology*
Clomipramine / pharmacology
Clorgyline / pharmacology
Corticosterone / blood*
Imipramine / pharmacology
Rats, Inbred Strains
Receptors, Glucocorticoid / analysis
Species Specificity
Reg. No./Substance:
0/Antidepressive Agents; 0/Receptors, Glucocorticoid; 17780-72-2/Clorgyline; 303-49-1/Clomipramine; 50-22-6/Corticosterone; 50-49-7/Imipramine; 9002-60-2/Adrenocorticotropic Hormone

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