Document Detail

Attenuation of histopathological alterations of colon, liver and lung by dietary fibre of barley Rihane in azoxymethane-treated rats.
MedLine Citation:
PMID:  24295706     Owner:  NLM     Status:  In-Data-Review    
This study was carried out to determine the effect of dietary fibre (DF) of barley Rihane (BR) in the attenuation of colon, liver and lung histopathology alterations induced by azoxymethane (AOM) in rats. Rats were fed a control (C) or experimental diet containing 30% of BR. The intended rats for cancer treatment received two successive subcutaneous injections of azoxymethane (AOM) at 20mg/kg body weight. The colons were analyzed for crypt multiplicity after 12weeks of treatment. A histological study of the colon, liver and lungs was determined. The results showed that the BR diet significantly reduced the number of aberrant crypt per focus and altered their distribution. In addition, DF of BR increased significantly the mucus secretion compared to control group. The use of the AOM as colon specific carcinogen substance altered the liver and lung architectures, whereas the presence of DF of BR could be a protective factor for these organs.
Lamia Lahouar; Fatma Ghrairi; Amira El Arem; Wala Sghaeir; Mouledi El Felah; Hichem Ben Salem; Badreddine Sriha; Lotfi Achour
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Publication Detail:
Type:  Journal Article     Date:  2013-11-01
Journal Detail:
Title:  Food chemistry     Volume:  149     ISSN:  0308-8146     ISO Abbreviation:  Food Chem     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2013-12-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7702639     Medline TA:  Food Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  271-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
Unité de Recherche 03/UR/09-01 «Génome, Diagnostic Immunitaire et valorisation», Institut Supérieur de Biotechnologie de Monastir, Université de Monastir, Avenue Tahar Haddad, BP 74, 5000 Monastir, Tunisia. Electronic address:
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