Document Detail

Attenuation of hemodynamic responses following laryngoscopy and tracheal intubation -- comparative assessment of clonidine and gabapentin premedication.
MedLine Citation:
PMID:  19583071     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The present study was conducted to compare the effect of clonidine and gabapentin premedication in modifying the hyperdynamic response following laryngoscopy and tracheal intubation.
METHODS AND MATERIALS: Seventy-five ASA I-II patients of both sexes (37 males (49.3%), 38 females (50.7%)) 18 to 45 years (mean 32.8 +/- 8.65 yr.) were randomly allocated into three equal groups (25 each). Group-1 received 0.2 mg clonidine, Group-2 received placebo and Group-3 received 900 mg gabapentin, 120 minute before operation. Heart rate, systolic, diastolic and mean arterial blood pressure were measured before induction of anesthesia, before laryngoscopy, and 1, 3, 5, 10 min after intubation.
RESULTS: Analysis revealed that the heart rate, systolic, diastolic and mean arterial blood pressure significantly differed between groups (p<0.001, p = 0.003, p<0.001, p<0.001, respectively). The highest rates of heart rate, systolic, diastolic and mean arterial blood pressure were in the placebo group and in one minute after laryngoscopy, and the lowest rate were in the gabapentin group at the time of 1, 3, 5 and 10 after laryngoscopy, except that the lowest rate of heart rate in 10 min after laryngoscopy was in clonidine group.
CONCLUSION: The data propose that both clonidine and gabapentin have effective role in blunting hyperdynamic responses after laryngoscopy, more so with gabapentin.
Seyed Mojtaba Marashi; Mohammad Hossein Ghafari; Alireza Saliminia
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Middle East journal of anaesthesiology     Volume:  20     ISSN:  0544-0440     ISO Abbreviation:  Middle East J Anaesthesiol     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-07-08     Completed Date:  2009-08-04     Revised Date:  2014-10-10    
Medline Journal Info:
Nlm Unique ID:  8604187     Medline TA:  Middle East J Anaesthesiol     Country:  Lebanon    
Other Details:
Languages:  eng     Pagination:  233-7     Citation Subset:  IM    
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MeSH Terms
Adrenergic alpha-Agonists / pharmacology
Amines / pharmacology*
Blood Pressure / drug effects
Clonidine / pharmacology*
Cyclohexanecarboxylic Acids / pharmacology*
Excitatory Amino Acid Antagonists / pharmacology
Heart Rate / drug effects
Intubation, Intratracheal / adverse effects*,  methods
Laryngoscopy / adverse effects*,  methods
Middle Aged
Time Factors
Young Adult
gamma-Aminobutyric Acid / pharmacology*
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Amines; 0/Cyclohexanecarboxylic Acids; 0/Excitatory Amino Acid Antagonists; 56-12-2/gamma-Aminobutyric Acid; 6CW7F3G59X/gabapentin; MN3L5RMN02/Clonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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