| Attenuation of exposure-response curves in occupational cohort studies at high exposure levels. | |
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MedLine Citation:
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PMID: 12934726 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Numerous occupational cohort mortality studies have observed exposure-response curves to have an increasing slope at low exposure levels that attenuates or even turns negative at high exposure levels. Examples discussed in this paper include dioxin, silica, 1,3-butadiene, cadmium, beryllium, radon daughters, diesel fumes, nickel, arsenic, and hexavalent chromium. Possible explanations for this phenomenon include (i) bias introduced by the healthy worker survivor effect, (ii) a depletion of the number of susceptible people in the population at high exposure levels, (iii) a natural limit on the relative risk for diseases with a high background rate, (iv) mismeasurement or misclassification of exposures, (v) the influence of other risk factors that vary by the level of the main exposure, and (vi) the saturation of key enzyme systems or other processes involved in the development of disease. |
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Authors:
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Leslie Stayner; Kyle Steenland; Mustafa Dosemeci; Irva Hertz-Picciotto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian journal of work, environment & health Volume: 29 ISSN: 0355-3140 ISO Abbreviation: Scand J Work Environ Health Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-08-25 Completed Date: 2003-12-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7511540 Medline TA: Scand J Work Environ Health Country: Finland |
Other Details:
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Languages: eng Pagination: 317-24 Citation Subset: IM |
Affiliation:
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Risk Evaluation Branch, Education and Information Division, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, United States. LStayner@cdc.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Causality Cohort Studies Dose-Response Relationship, Drug Hazardous Substances / adverse effects Healthy Worker Effect Humans Occupational Diseases / chemically induced, epidemiology, mortality* Occupational Exposure / adverse effects*, statistics & numerical data Risk Assessment* Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Hazardous Substances |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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