Document Detail

Attenuation of endothelium-related relaxation and enhanced responsiveness of vascular smooth muscle to histamine in spastic coronary arterial segments from miniature pigs.
MedLine Citation:
PMID:  3119249     Owner:  NLM     Status:  MEDLINE    
Mechanism of coronary spasm was examined regarding endothelium-related relaxation and contraction produced by smooth muscle cells of spastic vessels isolated from Göttingen miniature pigs. In these pigs, coronary artery spasm was documented angiographically in vivo three months after endothelial denudation, and spastic and control segments of the coronary artery were suspended in organ chambers at their optimal length for generating tension. Applications of KCl (118 mM), acetylcholine(10(-9) to 10(-4) M), and PGF2 alpha (10(-8) to 3 X 10(-5) M) produced similar tension, at the respective doses, in both the spastic and control coronary arteries. During increasing concentrations of histamine (10(-8) to 3 X 10(-4) M; n = 14) and serotonin (10(-9) to 10(-5) M; n = 13), the maximum tension of the spastic vessel was 136 +/- 6 and 97 +/- 4%, respectively, of the tension produced by 118 mM KCl. That is significantly larger than seen in the control vessels: 98 +/- 4 and 74 +/- 4%, respectively. The ED50 to histamine and serotonin was also significantly less in the spastic vessels. After mechanical removal of the endothelium, the tension generated during the cumulative administration of histamine (n = 8) but not serotonin (n = 8) was larger in the spastic than the control vessels, thereby suggesting the presence of augmented responses of the smooth muscle to histamine in the spastic vessels. The increase in maximum tension after mechanical denudation was greater in the control than the spastic vessels in cases of histamine and serotonin.(ABSTRACT TRUNCATED AT 250 WORDS)
Y Yamamoto; H Tomoike; K Egashira; M Nakamura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation research     Volume:  61     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-01-12     Completed Date:  1988-01-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  772-8     Citation Subset:  IM    
Research Institute of Angiocardiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Calcimycin / pharmacology
Coronary Vasospasm / physiopathology*
Disease Models, Animal
Endothelium, Vascular / physiopathology*
Histamine / pharmacology*
Ketanserin / pharmacology
Muscle Contraction / drug effects
Muscle Relaxation
Muscle, Smooth, Vascular / drug effects,  physiopathology*
Prostaglandins F / pharmacology
Serotonin / pharmacology
Swine, Miniature
Reg. No./Substance:
0/Prostaglandins F; 50-67-9/Serotonin; 51-45-6/Histamine; 52665-69-7/Calcimycin; 551-11-1/Dinoprost; 74050-98-9/Ketanserin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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