Document Detail

Attenuation of diabetic complications by C-phycoerythrin in rats: antioxidant activity of C-phycoerythrin including copper-induced lipoprotein and serum oxidation.
MedLine Citation:
PMID:  19123960     Owner:  NLM     Status:  MEDLINE    
In the present study, the protective role of purified C-phycoerythrin (C-PE) against diabetic complications and Cu-mediated lipoprotein oxidation was evaluated. C-PE (25 and 50 mg/kg body weight per d) was administered to experimental streptozotocin-nicotinamide-induced type 2 diabetic male rats for 28 d. C-PE treatment successfully ameliorated diabetic complications by decreasing food intake, organ weights, serum concentrations of glucose, cholesterol, TAG, VLDL-cholesterol, creatinine, uric acid and thiobarbituric acid-reactive substances (TBARS), with increases in body weight, Hb, total protein, bilirubin and ferric-reducing ability of plasma values. Hepatic and renal tissues demonstrated significant decreases in TBARS, lipid hydroperoxide and conjugated diene contents, with increases in superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione, vitamin E and vitamin C levels. Furthermore, the 4-week ex vivo and in vitro administration of C-PE (0.5 and 1.0 mg/ml) indicated a decrease in Cu-mediated serum oxidation. The kinetics of the LDL oxidation profile showed significant prolongation of the lag phase with declines in oxidation rate, conjugated dienes, lipid hydroperoxide and TBARS. Results indicated the involvement of C-PE in the amelioration of diabetic complications by significant reductions in oxidative stress and oxidised LDL-triggered atherogenesis.
Badrish Soni; Nishant P Visavadiya; Datta Madamwar
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-05
Journal Detail:
Title:  The British journal of nutrition     Volume:  102     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-06     Completed Date:  2009-08-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  102-9     Citation Subset:  IM    
BRD School of Biosciences, Sardar Patel Maidan, Vadtal Road, Satellite Campus, Post Box 39, Sardar Patel University, Vallabh Vidyanagar 388 120, Gujarat, India.
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MeSH Terms
Antioxidants / administration & dosage*
Biological Markers / blood
Catalase / blood
Copper / administration & dosage
Diabetes Complications / blood,  drug therapy*
Diabetes Mellitus, Experimental
Dose-Response Relationship, Drug
Glutathione / blood
Lipid Peroxidation
Oxidative Stress
Phycoerythrin / administration & dosage*
Phytotherapy / methods*
Random Allocation
Rats, Inbred Strains
Superoxide Dismutase / blood
Thiobarbituric Acid Reactive Substances / analysis
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; 0/Thiobarbituric Acid Reactive Substances; 11016-17-4/Phycoerythrin; 70-18-8/Glutathione; 7440-50-8/Copper; EC; EC Dismutase

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