Document Detail

Attenuation of cardioprotective effect by postconditioning in coronary stenosed rat heart and its restoration by carvedilol.
MedLine Citation:
PMID:  18946174     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of this study was to assess whether and how infarct size (IS) reduction by postconditioning is modified in the heart with coronary stenosis (CS), and how beta-blocker treatment affects it.
METHODS AND RESULTS: The IS was assessed by 30-min acute coronary occlusion and 24-h reperfusion in rat hearts in which CS had been induced. Modification of IS by postconditioning and the effects of daily carvedilol treatment were measured, together with reperfusion injury - salvage kinase activities. Four weeks after CS induction, any reduction of IS by postconditioning was lost, whereas it reduced IS in rats without CS. In the hearts without CS, postconditioning activated both the ERK and Akt pathway. However, in the hearts with CS, postconditioning failed to do so. In hearts with CS plus daily carvedilol treatment, postconditioning reduced IS compared with the hearts without carvedilol, although postconditioning did not activate the Akt and ERK pathways.
CONCLUSION: CS impaired Akt and ERK activation, resulting in a failure to reduce IS by postconditioning. Carvedilol treatment restored the IS reduction by postconditioning, possibly via other mechanism(s) of the ERK and Akt pathways.
Masayoshi Oikawa; Hiroyuki Yaoita; Kenichi Watanabe; Yukio Maruyama
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Publication Detail:
Type:  Journal Article     Date:  2008-10-21
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  72     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-25     Completed Date:  2009-03-20     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  2081-6     Citation Subset:  IM    
First Department of Internal Medicine, Fukushima Medical University, Fukushima, Japan.
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology*
Carbazoles / pharmacology*
Coronary Stenosis / complications,  drug therapy,  pathology,  therapy*
Disease Models, Animal
Extracellular Signal-Regulated MAP Kinases / metabolism
Myocardial Infarction / etiology,  pathology,  prevention & control*
Myocardial Reperfusion / methods*
Myocardial Reperfusion Injury / etiology,  pathology,  prevention & control*
Myocardium / enzymology,  pathology
Propanolamines / pharmacology*
Proto-Oncogene Proteins c-akt / metabolism
Rats, Sprague-Dawley
Signal Transduction / drug effects
Time Factors
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Carbazoles; 0/Propanolamines; 0K47UL67F2/carvedilol; EC Proteins c-akt; EC Signal-Regulated MAP Kinases

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