Document Detail

Attenuation of blood parameters in smokers and non-smokers after intake of a complex food additive.
MedLine Citation:
PMID:  12622238     Owner:  NLM     Status:  MEDLINE    
This report describes an intervention study with healthy volunteers (20 smokers, 28 non-smokers) taking a food additive mainly containing vitamin C (ascorbic acid), vitamin E (alpha-tocopherol), ubiquinone (Q10), vitamin A and zinkoxide for four weeks in a double blind, randomized and placebo controlled manner. Before and after the intervention blood was withdrawn and general blood parameters were analyzed. In addition, lipid soluble antioxidants were analyzed in blood plasma by HPLC and the water soluble antioxidative properties were tested with the enzymic xanthin/xanthinoxidase-reaction. In summary the results show that the smoker-verum group exhibit a significant down regulation of the leukocyte counts. The test for antioxidants show the following significant differences after intervention: Smokers exhibit an increase of both vitamin E and coenzyme Q10 and an attenuation of their (before intervention) clearly increased water soluble-antioxidative potential, non-smokers showed only an increase of vitamin E and trends of an increase of Q10 and water soluble-antioxidative potential. These results may contribute to the discussion of the intrinsic deficiency brought about by smoking and the possible attenuation of part of these deficiency by increasing the intake of certain vitamins or food additives.
Susanne Hippeli; Kerstin Dornisch; Martina Brink; Rudolf Lorenz; Dieter Jeschke; Erich F Elstner
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Zeitschrift für Naturforschung. C, Journal of biosciences     Volume:  58     ISSN:  0939-5075     ISO Abbreviation:  Z. Naturforsch., C, J. Biosci.     Publication Date:    2003 Jan-Feb
Date Detail:
Created Date:  2003-03-07     Completed Date:  2003-04-28     Revised Date:  2009-11-04    
Medline Journal Info:
Nlm Unique ID:  8912155     Medline TA:  Z Naturforsch C     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  119-27     Citation Subset:  IM    
IsarLabSystems, Dr. Hippeli und Dr. Domisch GBR, Gartenstr.1, 85354 Freising, Germany.
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MeSH Terms
Ascorbic Acid / blood,  pharmacology*
Chromatography, High Pressure Liquid
Erythrocytes / drug effects,  metabolism
Food Additives* / pharmacology
Hemoglobins / drug effects,  metabolism
Leukocyte Count
Lymphocyte Count
Neutrophils / drug effects,  physiology
Reference Values
Smoking / blood*
Vitamin E / blood,  pharmacology*
Xanthine Oxidase / metabolism
Reg. No./Substance:
0/Food Additives; 0/Hemoglobins; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; EC Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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