Document Detail

Attenuation of apoptosis by telmisartan in atherosclerotic plaques of apolipoprotein e-/- mice: evaluation using technetium 99m-annexin a5.
MedLine Citation:
PMID:  23763985     Owner:  NLM     Status:  In-Data-Review    
AbstractTechnetium 99m (99mTc)-annexin A5, a marker of ongoing apoptosis, is supposed to be useful in the detection of metabolically active atheroma. The aim of this study was to determine the potential of 99mTc-annexin A5 for evaluating the therapeutic effects of an angiotensin II receptor type 1 blocker (ARB) (telmisartan) on atherosclerosis. Male apolipoprotein E-/- mice were divided into telmisartan-treated (3 mg/kg/d, n  =  10) and control (n  =  10) groups. After 16 to 21 weeks of treatment, 99mTc-annexin A5 was injected and cryostat sections of aortic tissues (n  =  10-12/aorta) were prepared. The 99mTc-annexin A5 accumulation level in the plaques was evaluated by autoradiography. Serial sections of the plaques were histologically examined to identify the lesion phenotypes (normal vessels, early lesions, atheromatous lesions, and fibrotic lesions), plaque size, macrophage infiltration levels, and lipid deposition levels. Telmisartan treatment significantly decreased the plaque size (0.05 ± 0.05 vs 0.11 ± 0.08, mm2), macrophage infiltration level (0.02 ± 0.02 vs 0.03 ± 0.02, mm2), lipid deposition level (0.01 ± 0.01 vs 0.02 ± 0.02, mm2), and 99mTc-annexin A5 accumulation level (1.30 ± 1.09 vs 2.15 ± 1.91, × 10-6/g). 99mTc-annexin A5 accumulation levels in the plaques positively correlated with macrophage infiltration (r  =  .69, p < .05) and lipid deposition (r  =  .66, p < .05) levels. Apoptosis imaging with 99mTc-annexin A5 may be useful for evaluating the therapeutic effects of ARBs on atherosclerosis.
Yan Zhao; Songji Zhao; Yuji Kuge; H William Strauss; Francis G Blankenberg; Nagara Tamaki
Related Documents :
22028915 - Endogenous epoxygenases are modulators of monocyte/macrophage activity.
12645935 - A novel ligand for the nkg2d receptor activates nk cells and macrophages and induces tu...
11880315 - Activation of type ii alveolar epithelial cells during acute endotoxemia.
23320145 - Cytokine and chemokine profile in individuals with different degrees of periportal fibr...
10227985 - Orally induced peripheral nonresponsiveness is maintained in the absence of functional ...
14688355 - Stat1 plays a critical role in the regulation of antimicrobial effector mechanisms, but...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular imaging     Volume:  12     ISSN:  1536-0121     ISO Abbreviation:  Mol Imaging     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-06-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101120118     Medline TA:  Mol Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  300-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Impact of a flattening filter free linear accelerator on structural shielding design.
Next Document:  Health-related quality of life - using the 15D instrument - of young adults with type 1 diabetes sin...