Document Detail


Attenuation of acute lung injury with propofol in endotoxemia.
MedLine Citation:
PMID:  15728072     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Endotoxin causes acute lung injury (ALI) through many mediators of inflammatory and immune responses. Propofol is an antiinflammatory and immunosuppressive drug. We conducted this study to evaluate whether propofol attenuates ALI associated with endotoxemia. Thirty-two anesthetized rabbits were randomly divided into four groups (n = 8 each). ALI was induced by IV endotoxin 5 mg/kg over 30 min in 3 groups. In 2 of the ALI groups, IV administration of propofol (2 or 5 mg/kg as a bolus followed by continuous infusion at 4 or 15 mg x kg(-1) x h(-1)) was started 15 min before endotoxin. The other ALI group received soybean-oil emulsion. The nonlung injury control group received infusion of both vehicles. The lungs were mechanically ventilated with 40% oxygen for 6 h after endotoxin. Hemodynamics did not differ among groups. The large dose of propofol attenuated lung leukosequestration, pulmonary edema (as assessed by lung wet/dry weight ratio), and pulmonary hyperpermeability (as assessed by albumin levels in bronchoalveolar lavage fluid) and resulted in better oxygenation, lung mechanics, and histological change. The small dose of propofol failed to do so. Our findings suggest that a large dose of propofol successfully mitigates physiological, biochemical, and histological deterioration in ALI in endotoxemia.
Authors:
Yumiko Takao; Katsuya Mikawa; Kahoru Nishina; Hidefumi Obara
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  100     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-02-24     Completed Date:  2005-03-18     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  810-6, table of contents     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesia & Perioperative Medicine, Faculty of Medical Sciences, Kobe University Graduate School of Medicine, Kusunoki-cho 7, Chuo-ku, Kobe 650-0017, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Endotoxemia / complications*,  pathology
Lung / pathology
Male
Nitric Oxide Synthase / genetics
Peroxynitrous Acid / metabolism
Propofol / therapeutic use*
RNA, Messenger / analysis
Rabbits
Respiratory Distress Syndrome, Adult / drug therapy*,  physiopathology
Chemical
Reg. No./Substance:
0/RNA, Messenger; 14691-52-2/Peroxynitrous Acid; 2078-54-8/Propofol; EC 1.14.13.39/Nitric Oxide Synthase

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