| Attenuation of acute lung injury with propofol in endotoxemia. | |
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MedLine Citation:
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PMID: 15728072 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endotoxin causes acute lung injury (ALI) through many mediators of inflammatory and immune responses. Propofol is an antiinflammatory and immunosuppressive drug. We conducted this study to evaluate whether propofol attenuates ALI associated with endotoxemia. Thirty-two anesthetized rabbits were randomly divided into four groups (n = 8 each). ALI was induced by IV endotoxin 5 mg/kg over 30 min in 3 groups. In 2 of the ALI groups, IV administration of propofol (2 or 5 mg/kg as a bolus followed by continuous infusion at 4 or 15 mg x kg(-1) x h(-1)) was started 15 min before endotoxin. The other ALI group received soybean-oil emulsion. The nonlung injury control group received infusion of both vehicles. The lungs were mechanically ventilated with 40% oxygen for 6 h after endotoxin. Hemodynamics did not differ among groups. The large dose of propofol attenuated lung leukosequestration, pulmonary edema (as assessed by lung wet/dry weight ratio), and pulmonary hyperpermeability (as assessed by albumin levels in bronchoalveolar lavage fluid) and resulted in better oxygenation, lung mechanics, and histological change. The small dose of propofol failed to do so. Our findings suggest that a large dose of propofol successfully mitigates physiological, biochemical, and histological deterioration in ALI in endotoxemia. |
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Authors:
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Yumiko Takao; Katsuya Mikawa; Kahoru Nishina; Hidefumi Obara |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anesthesia and analgesia Volume: 100 ISSN: 0003-2999 ISO Abbreviation: Anesth. Analg. Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-02-24 Completed Date: 2005-03-18 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: United States |
Other Details:
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Languages: eng Pagination: 810-6, table of contents Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesia & Perioperative Medicine, Faculty of Medical Sciences, Kobe University Graduate School of Medicine, Kusunoki-cho 7, Chuo-ku, Kobe 650-0017, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Endotoxemia / complications*, pathology Lung / pathology Male Nitric Oxide Synthase / genetics Peroxynitrous Acid / metabolism Propofol / therapeutic use* RNA, Messenger / analysis Rabbits Respiratory Distress Syndrome, Adult / drug therapy*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 14691-52-2/Peroxynitrous Acid; 2078-54-8/Propofol; EC 1.14.13.39/Nitric Oxide Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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