Document Detail

Attenuation of mouse melanoma by A/C magnetic field after delivery of bi-magnetic nanoparticles by neural progenitor cells.
MedLine Citation:
PMID:  21058696     Owner:  NLM     Status:  MEDLINE    
Localized magnetic hyperthermia as a treatment modality for cancer has generated renewed interest, particularly if it can be targeted to the tumor site. We examined whether tumor-tropic neural progenitor cells (NPCs) could be utilized as cell delivery vehicles for achieving preferential accumulation of core/shell iron/iron oxide magnetic nanoparticles (MNPs) within a mouse model of melanoma. We developed aminosiloxane-porphyrin functionalized MNPs, evaluated cell viability and loading efficiency, and transplanted neural progenitor cells loaded with this cargo into mice with melanoma. NPCs were efficiently loaded with core/shell Fe/Fe(3)O(4) MNPs with minimal cytotoxicity; the MNPs accumulated as aggregates in the cytosol. The NPCs loaded with MNPs could travel to subcutaneous melanomas, and after A/C (alternating current) magnetic field (AMF) exposure, the targeted delivery of MNPs by the cells resulted in a measurable regression of the tumors. The tumor attenuation was significant (p < 0.05) a short time (24 h) after the last of three AMF exposures.
Raja Shekar Rachakatla; Sivasai Balivada; Gwi-Moon Seo; Carl B Myers; Hongwang Wang; Thilani N Samarakoon; Raj Dani; Marla Pyle; Franklin O Kroh; Brandon Walker; Xiaoxuan Leaym; Olga B Koper; Viktor Chikan; Stefan H Bossmann; Masaaki Tamura; Deryl L Troyer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-11-08
Journal Detail:
Title:  ACS nano     Volume:  4     ISSN:  1936-086X     ISO Abbreviation:  ACS Nano     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-28     Completed Date:  2011-03-23     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  101313589     Medline TA:  ACS Nano     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7093-104     Citation Subset:  IM    
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MeSH Terms
Biological Transport
Cell Line, Tumor
Electric Conductivity*
Ferric Compounds / chemistry,  metabolism
Iron / chemistry,  metabolism
Magnetic Field Therapy / methods*
Melanoma / metabolism*,  pathology,  therapy*
Nervous System / cytology*
Stem Cell Transplantation
Stem Cells / metabolism*
Grant Support
1R21CA135599/CA/NCI NIH HHS; HHSN261200800059C//PHS HHS; R21 CA135599/CA/NCI NIH HHS; R21 CA135599-01/CA/NCI NIH HHS
Reg. No./Substance:
0/Ferric Compounds; 1309-37-1/ferric oxide; E1UOL152H7/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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