Document Detail


Attenuation of KBrO(3) -Induced Renal and Hepatic Toxicity By Cloudy Apple Juice In Rat.
MedLine Citation:
PMID:  23042583     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The aim of the study was to evaluate a protective effect of apple juice on KBrO(3) -induced oxidative stress in rats. Male Wistar rats were administered apple juice per os, 10 ml/kg b.w. for 28 days. On 27 day of the experiment, some rats were given i.p. a single 125 mg/kg b.w. dose of KBrO(3) . Markers of oxidative damage and clinical chemistry parameters were determined. Treatment with apple juice prior to KBrO(3) challenge prevented an increase in hepatic and renal microsomal lipid peroxidation by 25 and 44%, respectively, increased the activity of antioxidant enzymes in the liver by 29 - 59% and decreased the plasma content of carbonyl groups by 19%. Aminotransferases activity in plasma was reduced by 19% and 36%, concentrations of plasma bilirubin, cholesterol and creatinine were suppressed by 21%, 16% and 26%, respectively, in rats supplemented with juice before KBrO(3) injection. No protective effect of apple juice on nuclear DNA was observed. Supplementation with cloudy apple juice to some extent attenuated oxidative damage induced by KBrO(3) in the liver and kidney of rats as evidenced by alterations of certain oxidative stress markers and clinical chemistry parameters. Copyright © 2012 John Wiley & Sons, Ltd.
Authors:
Małgorzata Kujawska; Ewa Ignatowicz; Małgorzata Ewertowska; Teresa Adamska; Jarosław Markowski; Jadwiga Jodynis-Liebert
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-8
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  -     ISSN:  1099-1573     ISO Abbreviation:  Phytother Res     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 John Wiley & Sons, Ltd.
Affiliation:
Department of Toxicology, Poznań University of Medical Sciences, Poznań, Poland.
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