| Attenuation of Helicteres isora L. bark extracts on streptozotocin-induced alterations in glycogen and carbohydrate metabolism in albino rats. | |
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MedLine Citation:
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PMID: 19812119 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study was undertaken to assess the effect of Helicteres isora L. on four important enzymes of carbohydrate metabolism (glucokinase [GK], hexokinase [HK] phosphofructokinase [PFK] and fructose-1, 6-bisphosphatase [FBP]) along with glycogen content of insulin-dependent (skeletal muscle and liver) and insulin-independent tissues (kidneys and brain) in streptozotocin (STZ; 60 mg/kg)-induced model of diabetes for 30 days. Administration of bark extracts (100, 200 mg/kg) for 30 days led to decrease in plasma glucose levels by approximately 9.60% and 22.04% and 19.18% and 33.93% on 15th and 30th day, respectively, of the experiment. Liver and two-kidney weight expressed as percentage of body weight significantly increased in diabetics (P < 0.05) versus normal controls. Renal glycogen content increased by 10 folds while hepatic and skeletal muscle glycogen content decreased by 75% and 68% in diabetic controls versus controls. H. isora did not affect glycogen content in any tissue. The decreased activities of PFK, GK, FBP and HK in diabetic controls were 40%, 50%, 50% and 60% and bark extract of H. isora partially corrected this alteration. The efficacy of the bark extract was comparable with Tolbutamide, a well-known hypoglycemic drug. |
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Authors:
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G Kumar; G Sharmila Banu; A G Murugesan |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2009-10-07 |
Journal Detail:
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Title: Human & experimental toxicology Volume: 28 ISSN: 1477-0903 ISO Abbreviation: Hum Exp Toxicol Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-17 Completed Date: 2010-01-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9004560 Medline TA: Hum Exp Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 689-96 Citation Subset: IM |
Affiliation:
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Division of Industrial Toxicology and Pollution Control, Manonmaniam Sundaranar University, Sri Paramakalyani Centre for Environmental Sciences, Alwarkurichi, Tamil Nadu, India. pgsvedhakumar@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / analysis Body Weight / drug effects Carbohydrate Metabolism / drug effects* Diabetes Mellitus, Experimental / metabolism* Glycogen / metabolism* Kidney / drug effects Liver / drug effects Organ Size / drug effects Plant Bark / chemistry* Plant Extracts / pharmacology* Rats Rats, Wistar Sterculiaceae / chemistry* Streptozocin |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Plant Extracts; 18883-66-4/Streptozocin; 9005-79-2/Glycogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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