| Attenuation of CNS inflammatory responses by nicotine involves α7 and non-α7 nicotinic receptors. | |
| | |
MedLine Citation:
|
PMID: 20932827 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A considerable number of in vivo studies have demonstrated that the cholinergic system can dampen the peripheral immune response, and it is thought that the α7-nicotinic acetylcholine receptor (nAChR) subtype is a key mediator of this process. The goal of the present study was to determine if nicotine modulates immunological mechanisms known to be involved in the development of experimental autoimmune encephalomyelitis (EAE), a mouse model for CNS autoimmune disease, via α7-nAChRs. Here we show that nicotine exposure attenuates EAE severity and that this effect is largely abolished in nAChR α7 subunit knock-out mice. However, nicotine exposure partially retains the ability to reduce lymphocyte infiltration into the CNS, inhibit auto-reactive T cell proliferation and helper T cell cytokine production, down-regulate co-stimulatory protein expression on myeloid cells, and increase the differentiation and recruitment of regulatory T cells, even in the absence of α7-nAChRs. Diverse effects of nicotine on effector and regulatory T cells, as well as antigen-presenting cells, may be linked to differential expression patterns of nAChR subunits across these cell types. Taken together, our data show that although α7-nAChRs indeed seem to play an important role in nicotine-conferred reduction of the CNS inflammatory response and protection against EAE, other nAChR subtypes also are involved in the anti-inflammatory properties of the cholinergic system. |
| | |
Authors:
|
Junwei Hao; Alain R Simard; Gregory H Turner; Jie Wu; Paul Whiteaker; Ronald J Lukas; Fu-Dong Shi |
Related Documents
:
|
11813877 - Connecting cytokines and brain: a review of current issues. 19570027 - Inflammatory cytokines il-1beta and tnf-alpha regulate p75ntr expression in cns neurons... 18771807 - Leukemia inhibitory factor modulates production of inflammatory mediators and myelin ph... 17618967 - Cns injury biomechanics and experimental models. 12228167 - Low levels of apoptosis and high flip expression in early rheumatoid arthritis synovium. 21934657 - Human msc suppression correlates with cytokine induction of indoleamine 2,3-dioxygenase... |
Publication Detail:
|
Type: Journal Article Date: 2010-10-13 |
Journal Detail:
|
Title: Experimental neurology Volume: 227 ISSN: 1090-2430 ISO Abbreviation: Exp. Neurol. Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-01-10 Completed Date: 2011-02-04 Revised Date: 2012-03-07 |
Medline Journal Info:
|
Nlm Unique ID: 0370712 Medline TA: Exp Neurol Country: United States |
Other Details:
|
Languages: eng Pagination: 110-9 Citation Subset: IM |
Copyright Information:
|
2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Division of Neurology, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antigens, CD / metabolism Cell Differentiation / drug effects, genetics Cell Proliferation / drug effects Central Nervous System / drug effects*, immunology, pathology Cytokines / genetics, metabolism Disease Models, Animal Encephalomyelitis, Autoimmune, Experimental / drug therapy*, genetics, pathology* Flow Cytometry / methods Gene Expression Regulation / drug effects, genetics Lymph Nodes / drug effects, pathology Magnetic Resonance Imaging / methods Mice Mice, Knockout Nicotine / therapeutic use* Nicotinic Agonists / therapeutic use* RNA, Messenger / metabolism Receptors, Nicotinic / deficiency, genetics, metabolism* Spleen / drug effects, pathology Statistics, Nonparametric T-Lymphocytes, Regulatory / drug effects, pathology |
| Grant Support | |
ID/Acronym/Agency:
|
R01 AI083294-01A1/AI/NIAID NIH HHS; R01 AI083294-03/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, CD; 0/Cytokines; 0/Nicotinic Agonists; 0/RNA, Messenger; 0/Receptors, Nicotinic; 0/alpha7 nicotinic acetylcholine receptor; 54-11-5/Nicotine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Efficacy of olfactory ensheathing cells to support regeneration after spinal cord injury is influenc...
Next Document: Wind-up of stretch reflexes as a measure of spasticity in chronic spinalized rats: The effects of pa...