Document Detail

Attenuated ventilatory response to hypoxaemia at vecuronium-induced partial neuromuscular block.
MedLine Citation:
PMID:  1359723     Owner:  NLM     Status:  MEDLINE    
The effect of a partial neuromuscular block on the ventilatory response to hypercarbia and to hypoxaemia was studied in 11 non-anaesthetized male subjects. Respiratory frequency, tidal volume, minute volume, respiratory timing and drive were measured during air breathing and during stimulation by hypercarbia and hypoxaemia. The ventilatory response was defined as the ratio between, respectively, tidal volume and minute volume during ventilation stimulated by hypercarbia and hypoxaemia compared to measurements during air breathing. The ventilatory measurements were repeated on three separate occasions: before neuromuscular block was established, during an infusion of vecuronium aiming at a mechanical adductor pollicis train-of-four (TOF) ratio of 0.70, and after the infusion had been stopped and the neuromuscular block had spontaneously recovered to a TOF ratio of > 0.90. Resting ventilation during air breathing remained with minor variations throughout the experiment. The ventilatory response to hypercarbia was not affected at a TOF ratio of 0.70 as compared to measurements before vecuronium and at a TOF ratio of > 0.90. In contrast, the ventilatory response to hypoxaemia was markedly reduced at a TOF ratio of 0.70. We conclude that a mechanical TOF ratio of 0.70 following vecuronium may be associated with an inadequate ventilatory response to hypoxaemia.
L I Eriksson; C Lennmarken; N Wyon; A Johnson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  36     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1992-12-07     Completed Date:  1992-12-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  710-5     Citation Subset:  IM; S    
Department of Anaesthesiology, Faculty of Health Sciences, University of Linköping, Sweden.
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MeSH Terms
Anoxia / physiopathology*
Blood Pressure / drug effects,  physiology
Carbon Dioxide / analysis
Electric Stimulation
Heart Rate / drug effects,  physiology
Hypercapnia / physiopathology*
Muscles / drug effects
Neuromuscular Junction / drug effects*
Respiration / drug effects*,  physiology*
Synaptic Transmission / drug effects*
Tidal Volume / drug effects
Time Factors
Ulnar Nerve / physiology
Vecuronium Bromide / pharmacology*
Reg. No./Substance:
124-38-9/Carbon Dioxide; 50700-72-6/Vecuronium Bromide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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