Document Detail


Attenuated ventilatory response to hypoxaemia at vecuronium-induced partial neuromuscular block.
MedLine Citation:
PMID:  1359723     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of a partial neuromuscular block on the ventilatory response to hypercarbia and to hypoxaemia was studied in 11 non-anaesthetized male subjects. Respiratory frequency, tidal volume, minute volume, respiratory timing and drive were measured during air breathing and during stimulation by hypercarbia and hypoxaemia. The ventilatory response was defined as the ratio between, respectively, tidal volume and minute volume during ventilation stimulated by hypercarbia and hypoxaemia compared to measurements during air breathing. The ventilatory measurements were repeated on three separate occasions: before neuromuscular block was established, during an infusion of vecuronium aiming at a mechanical adductor pollicis train-of-four (TOF) ratio of 0.70, and after the infusion had been stopped and the neuromuscular block had spontaneously recovered to a TOF ratio of > 0.90. Resting ventilation during air breathing remained with minor variations throughout the experiment. The ventilatory response to hypercarbia was not affected at a TOF ratio of 0.70 as compared to measurements before vecuronium and at a TOF ratio of > 0.90. In contrast, the ventilatory response to hypoxaemia was markedly reduced at a TOF ratio of 0.70. We conclude that a mechanical TOF ratio of 0.70 following vecuronium may be associated with an inadequate ventilatory response to hypoxaemia.
Authors:
L I Eriksson; C Lennmarken; N Wyon; A Johnson
Related Documents :
19179653 - Facial immersion in cold water enhances cerebral blood velocity during breath-hold exer...
12016103 - Phasic vagal influence on the rate and timing of reflex swallowing.
20407233 - Impact of prolonged low-grade physical training on the in vivo glucocorticoid sensitivi...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  36     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1992-12-07     Completed Date:  1992-12-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  710-5     Citation Subset:  IM; S    
Affiliation:
Department of Anaesthesiology, Faculty of Health Sciences, University of Linköping, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Anoxia / physiopathology*
Blood Pressure / drug effects,  physiology
Carbon Dioxide / analysis
Electric Stimulation
Heart Rate / drug effects,  physiology
Humans
Hypercapnia / physiopathology*
Male
Muscles / drug effects
Neuromuscular Junction / drug effects*
Respiration / drug effects*,  physiology*
Spirometry
Synaptic Transmission / drug effects*
Thumb
Tidal Volume / drug effects
Time Factors
Ulnar Nerve / physiology
Vecuronium Bromide / pharmacology*
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide; 50700-72-6/Vecuronium Bromide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The use of the bromocriptine test in schizophrenia patients resistant to neuroleptic therapy
Next Document:  Creutzfeldt-Jakob disease with codon 129 polymorphism (valine): a comparative study of patients with...