| Attenuated renal excretion in response to thiazide diuretics in Gitelman's syndrome: a case report. | |
| | |
| Jump to Full Text | |
MedLine Citation:
|
PMID: 12172059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Gitelman's syndrome is a variant of Bartter's syndrome characterized by hypocalciuria and hypomagnesemia. The administration of thiazide diuretics may induce a subnormal increase of urinary Na+ and Cl- excretion in patients with Gitelman's syndrome, consistent with the hypothesis that less Na+ and Cl- than normal is reabsorbed by the thiazide-inhibitable transporter in Gitelman's syndrome. Specific mutations of NaCl cotransporter, coupled with mutant NaCl cotransporter expression studies clearly demonstrated that many of the characteristics of individuals with Gitelman's syndrome are explained by lack of function of NaCl cotransporter. We recently diagnosed a patient with Gitelman's syndrome by performing the thiazide and furosemide tests, and it is suggested that the clearance studies by diuretic administration may be of diagnostic help in Gitelman's syndrome. |
| | |
Authors:
|
Chung-Ho Yeum; Soo-Wan Kim; Seong-Kwon Ma; Jung-Hee Ko; Myong-Yun Nah; Nam-Ho Kim; Ki-Chul Choi |
Related Documents
:
|
14734929 - Epileptic encephalopathies: a brief overview. 16902299 - Carbamazepine-induced hypersensitivity syndrome occurring in a photodistributed pattern. 2694139 - Sarcoidosis presenting with an acute guillain-barré syndrome. |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Journal of Korean medical science Volume: 17 ISSN: 1011-8934 ISO Abbreviation: J. Korean Med. Sci. Publication Date: 2002 Aug |
Date Detail:
|
Created Date: 2002-08-12 Completed Date: 2003-03-21 Revised Date: 2011-03-16 |
Medline Journal Info:
|
Nlm Unique ID: 8703518 Medline TA: J Korean Med Sci Country: Korea (South) |
Other Details:
|
Languages: eng Pagination: 567-70 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, Cheju National University Medical School, Jeju, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Bartter Syndrome / diagnosis*, metabolism, physiopathology Benzothiadiazines* Chlorides / blood, urine Diuretics / diagnostic use Electrolytes / blood, urine Female Furosemide / diagnostic use Humans Kidney / physiopathology* Kidney Function Tests Sodium / blood, urine Sodium Chloride Symporter Inhibitors / diagnostic use* Sodium Chloride Symporters Symporters / metabolism Syndrome |
| Chemical | |
Reg. No./Substance:
|
0/Benzothiadiazines; 0/Chlorides; 0/Diuretics; 0/Electrolytes; 0/Sodium Chloride Symporter Inhibitors; 0/Sodium Chloride Symporters; 0/Symporters; 54-31-9/Furosemide; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
|
Journal Information Journal ID (nlm-ta): J Korean Med Sci Journal ID (pmc): jkms ISSN: 1011-8934 ISSN: 1598-6357 Publisher: Korean Academy of Medical Sciences |
Article Information Download PDF  Print publication date: Month: 8 Year: 2002 Volume: 17 Issue: 4 First Page: 567 Last Page: 570 ID: 3054904 PubMed Id: 12172059 Publisher Item Identifier: 200208567 |
| Attenuated renal excretion in response to thiazide diuretics in Gitelman's syndrome: a case report. | |
| Chung-Ho Yeum | |
| Soo-Wan Kim | |
| Seong-Kwon Ma | |
| Jung-Hee Ko | |
| Myong-Yun Nah | |
| Nam-Ho Kim | |
| Ki-Chul Choi | |
| Department of Internal Medicine, Cheju National University Medical School, Jeju, Korea. |
|
Article Categories:
|
|
Previous Document: A case of second branchial cleft cyst with oropharyngeal presentation.
Next Document: Purulent pericarditis caused by group G streptococcus as an initial presentation of colon cancer.