Document Detail


Attenuated peptide YY release in obese subjects is associated with reduced satiety.
MedLine Citation:
PMID:  16166213     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The responses of the gut hormone peptide YY (PYY) to food were investigated in 20 normal-weight and 20 obese humans in response to six test meals of varying calorie content. Human volunteers had a graded rise in plasma PYY (R2 = 0.96; P < 0.001) during increasing calorific meals, but the obese subjects had a lower endogenous PYY response at each meal size (P < 0.05 at all levels). The ratio of plasma PYY(1-36) to PYY(3-36) was similar in normal-weight and obese subjects. The effect on food intake and satiety of graded doses of exogenous PYY(3-36) was also evaluated in 12 human volunteers. Stepwise increasing doses of exogenous PYY(3-36) in humans caused a graded reduction in food intake (R2 = 0.38; P < 0.001). In high-fat-fed (HF) mice that became obese and low-fat-fed mice that remained normal weight, we measured plasma PYY, tissue PYY, and PYY mRNA levels and assessed the effect of exogenous administered PYY(3-36) on food intake in HF mice. HF mice remained sensitive to the anorectic effects of exogenous ip PYY(3-36). Compared with low-fat-fed fed mice, the HF mice had lower endogenous plasma PYY and higher tissue PYY but similar PYY mRNA levels, suggesting a possible reduction of PYY release. Thus, fasting and postprandial endogenous plasma PYY levels were attenuated in obese humans and rodents. The PYY(3-36) infusion study showed that the degree of plasma PYY reduction in obese subjects were likely associated with decreased satiety and relatively increased food intake. We conclude that obese subjects have a PYY deficiency that would reduce satiety and could thus reinforce their obesity.
Authors:
C W le Roux; R L Batterham; S J B Aylwin; M Patterson; C M Borg; K J Wynne; A Kent; R P Vincent; J Gardiner; M A Ghatei; S R Bloom
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-09-15
Journal Detail:
Title:  Endocrinology     Volume:  147     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-20     Completed Date:  2006-02-03     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight
Eating / physiology
Energy Intake
Humans
Mice
Models, Animal
Obesity / physiopathology*
Peptide YY / secretion*
Postprandial Period / physiology*
Reference Values
Satiety Response / physiology*
Grant Support
ID/Acronym/Agency:
G108/551//Medical Research Council; //Wellcome Trust
Chemical
Reg. No./Substance:
106388-42-5/Peptide YY
Comments/Corrections
Comment In:
Endocrinology. 2006 Jan;147(1):1-2   [PMID:  16365139 ]

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