| Attenuated peptide YY release in obese subjects is associated with reduced satiety. | |
| | |
MedLine Citation:
|
PMID: 16166213 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The responses of the gut hormone peptide YY (PYY) to food were investigated in 20 normal-weight and 20 obese humans in response to six test meals of varying calorie content. Human volunteers had a graded rise in plasma PYY (R2 = 0.96; P < 0.001) during increasing calorific meals, but the obese subjects had a lower endogenous PYY response at each meal size (P < 0.05 at all levels). The ratio of plasma PYY(1-36) to PYY(3-36) was similar in normal-weight and obese subjects. The effect on food intake and satiety of graded doses of exogenous PYY(3-36) was also evaluated in 12 human volunteers. Stepwise increasing doses of exogenous PYY(3-36) in humans caused a graded reduction in food intake (R2 = 0.38; P < 0.001). In high-fat-fed (HF) mice that became obese and low-fat-fed mice that remained normal weight, we measured plasma PYY, tissue PYY, and PYY mRNA levels and assessed the effect of exogenous administered PYY(3-36) on food intake in HF mice. HF mice remained sensitive to the anorectic effects of exogenous ip PYY(3-36). Compared with low-fat-fed fed mice, the HF mice had lower endogenous plasma PYY and higher tissue PYY but similar PYY mRNA levels, suggesting a possible reduction of PYY release. Thus, fasting and postprandial endogenous plasma PYY levels were attenuated in obese humans and rodents. The PYY(3-36) infusion study showed that the degree of plasma PYY reduction in obese subjects were likely associated with decreased satiety and relatively increased food intake. We conclude that obese subjects have a PYY deficiency that would reduce satiety and could thus reinforce their obesity. |
| | |
Authors:
|
C W le Roux; R L Batterham; S J B Aylwin; M Patterson; C M Borg; K J Wynne; A Kent; R P Vincent; J Gardiner; M A Ghatei; S R Bloom |
Related Documents
:
|
16033253 - Biaryl ureas as potent and orally efficacious melanin concentrating hormone receptor 1 ... 19500623 - The power of food scale. a new measure of the psychological influence of the food envir... 17042143 - Use of complementary and alternative medicine by food-allergic patients. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-09-15 |
Journal Detail:
|
Title: Endocrinology Volume: 147 ISSN: 0013-7227 ISO Abbreviation: Endocrinology Publication Date: 2006 Jan |
Date Detail:
|
Created Date: 2005-12-20 Completed Date: 2006-02-03 Revised Date: 2007-08-13 |
Medline Journal Info:
|
Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: United States |
Other Details:
|
Languages: eng Pagination: 3-8 Citation Subset: AIM; IM |
Affiliation:
|
Department of Metabolic Medicine, 6th Floor Commonwealth Building, Hammersmith Hospital, Imperial College London, London W12 0NN, United Kingdom. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Body Weight Eating / physiology Energy Intake Humans Mice Models, Animal Obesity / physiopathology* Peptide YY / secretion* Postprandial Period / physiology* Reference Values Satiety Response / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
|
106388-42-5/Peptide YY |
| Comments/Corrections | |
Comment In:
|
Endocrinology. 2006 Jan;147(1):1-2
[PMID:
16365139
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Plasma protein and blood volume restitution after hemorrhage in conscious pregnant and ovarian stero...
Next Document: Oxygen-dependent modulation of insulin-like growth factor binding protein biosynthesis in primary cu...