Document Detail


Attenuated myocardial vasodilator response in patients with hypertensive hypertrophy revealed by oxygenation-dependent magnetic resonance imaging.
MedLine Citation:
PMID:  11551869     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Oxygen (O(2)) homeostasis is central to myocardial tissue functioning, and increased O(2) demand is thought to be satisfied by a vasodilatory mechanism that results in increased blood and O(2) delivery. We applied blood oxygenation level-dependent (BOLD) MRI in conjunction with vasodilatory stress to index the ability to augment intramyocardial oxygenation in hypertensive hypertrophy, the primary cause of heart failure. METHODS AND RESULTS: Nine healthy controls and 10 hypertensive subjects with moderate-to-severe hypertrophy underwent imaging on a 1.5 T clinical scanner. The dipyridamole-induced change in the apparent transverse relaxation rate, R2*, which correlates with hemoglobin oxygenation, was -5.4+/-2.2 s(-1) (95% CI, -4.0 to -6.8 s(-1)) in controls compared with -1.7+/-1.4 s(-1) (95% CI, -0.8 to -2.6 s(-1)) in hypertensive patients (P=0.0003). CONCLUSIONS: Patients with hypertensive hypertrophy demonstrate an impaired ability to increase intramyocardial oxygenation during vasodilatory stress, as indexed by BOLD MRI. The capacity to image vascular function with BOLD MRI may advance the understanding of the development of ventricular dysfunction in hypertension.
Authors:
G M Beache; D A Herzka; J L Boxerman; W S Post; S N Gupta; A Z Faranesh; M Solaiyappan; P A Bottomley; J L Weiss; E P Shapiro; M N Hill
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  104     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-09-11     Completed Date:  2001-10-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1214-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. gbeache@umm.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Coronary Circulation / drug effects
Coronary Vessels / drug effects,  physiopathology
Dipyridamole / administration & dosage,  diagnostic use
Female
Humans
Hypertension / blood,  complications,  physiopathology*
Hypertrophy, Left Ventricular / blood,  etiology,  physiopathology*
Magnetic Resonance Imaging / methods
Male
Middle Aged
Oxygen / blood*
Vasodilation* / drug effects
Vasodilator Agents / administration & dosage,  diagnostic use
Grant Support
ID/Acronym/Agency:
K01 HL03837/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 58-32-2/Dipyridamole; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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