Document Detail


Attenuated metabolic effect of waist measurement in Japanese female patients with type 2 diabetes mellitus.
MedLine Citation:
PMID:  18786739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Waist circumference (WC) was measured in 200 Japanese patients with type 2 diabetes mellitus (T2DM: male 106, female 94, mean age 61 years old) who had been admitted in our hospital, and relationship with various risk factors to predict future cardiovascular disease (CVD) was analyzed. There was a positive and statistically significant trend in WC levels with an increasing number of CVD risk factors in male patients, whereas no significant trend of WC was observed in female patients. The receiver operator characteristic (ROC) curve for WC to predict the presence of two or more risk factors of CVD depicted greater area under the curve in male patients (0.732) than that in female patients (0.571). Apart from positive correlation with fasting serum C-peptide (S-CPR) and log-transformed high-sensitivity C-reactive protein (log HS-CRP) in both genders, WC was positively correlated with log-transformed triglyceride (log TG), systolic and diastolic blood pressure (SBP and DBP) and negatively with HDL-cholesterol (HDL-C) in male patients, whereas it was negatively correlated with HbA1c and fasting plasma glucose (FPG) in female patients. The change of WC after administration (DeltaWC) was correlated with DeltaS-CPR, DeltaLDL-C, DeltaSBP and DeltaDBP in male patients, while no relationship was observed in female patients. In conclusion, WC is a reliable marker to predict future CVD events at least in Japanese male, but not female patients with T2DM.
Authors:
Yuji Tajiri; Ryoko Takei; Kazuo Mimura; Fumio Umeda
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Publication Detail:
Type:  Journal Article     Date:  2008-09-10
Journal Detail:
Title:  Diabetes research and clinical practice     Volume:  82     ISSN:  1872-8227     ISO Abbreviation:  Diabetes Res. Clin. Pract.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-06     Completed Date:  2009-02-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508335     Medline TA:  Diabetes Res Clin Pract     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  66-72     Citation Subset:  IM    
Affiliation:
Endocrinology and Metabolism Division, Kurume University School of Medicine, Kurume 830-0011, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Asian Continental Ancestry Group
Blood Pressure
C-Peptide / blood
C-Reactive Protein / metabolism
Cardiovascular Diseases / metabolism,  pathology
Diabetes Mellitus, Type 2 / metabolism*,  pathology
Female
Humans
Male
Middle Aged
Risk Factors
Triglycerides / metabolism
Waist Circumference / physiology*
Chemical
Reg. No./Substance:
0/C-Peptide; 0/Triglycerides; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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