| Attenuated lactate response to ischemic exercise in migraine. | |
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MedLine Citation:
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PMID: 20671614 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although the pathogenesis of migraine still remains unclear, certain metabolic studies done on patients with migraine indicate possible deficits in mitochondrial activity. Previously, the forearm ischemic exercise test (FIT) has been used as a screening tool to evaluate mitochondrial dysfunction in metabolic myopathies. MATERIAL/METHODS: We studied the response of migraine patients to exercise using the modified FIT and compared this to the responses in a healthy group. After baseline venous blood samples were drawn, a sphygmomanometer cuff placed around the upper arm was inflated to 30 mmHg above systolic blood pressure and the subject performed a maximal isometric contraction of the forearm flexors using a hand-grip dynamometer with a 9-contraction: 1-relaxation duty cycle for a total time of 60 seconds. RESULTS: In migraine patients, attenuated lactate response after the FIT in the 1st, 3rd and 5th minutes were significantly different when compared to the control group. CONCLUSIONS: Our results show that there may be defects in the anaerobic or proximal glycolytic pathways in migraine patients, evident in stressful situations. We also conclude that the FIT may be useful for research on migraine pathophysiology. |
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Authors:
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Sevki Sahin; Nilgun Cinar; Fehime Benli Aksungar; Sunay Ayalp; Sibel Karsidag |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Medical science monitor : international medical journal of experimental and clinical research Volume: 16 ISSN: 1643-3750 ISO Abbreviation: Med. Sci. Monit. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-30 Completed Date: 2010-11-03 Revised Date: 2011-06-14 |
Medline Journal Info:
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Nlm Unique ID: 9609063 Medline TA: Med Sci Monit Country: Poland |
Other Details:
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Languages: eng Pagination: CR378-82 Citation Subset: IM |
Affiliation:
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Department of Neurology, Faculty of Medicine, Maltepe University, Istanbul, Turkey. drsahin@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Glucose / metabolism Case-Control Studies Exercise Test / methods* Female Forearm / blood supply Humans Hydrogen-Ion Concentration Ischemia / blood* L-Lactate Dehydrogenase / metabolism Lactic Acid / blood* Migraine Disorders / blood*, physiopathology* Oxygen / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 50-21-5/Lactic Acid; 7782-44-7/Oxygen; EC 1.1.1.27/L-Lactate Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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