Document Detail


Attenuated inspiratory muscle metaboreflex in endurance-trained individuals.
MedLine Citation:
PMID:  21382525     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The inspiratory metaboreflex is activated during loaded breathing to task failure and induces sympathetic activation and peripheral vasoconstriction that may limit exercise performance. Inspiratory muscle training appears to attenuate the inspiratory metaboreflex in healthy subjects. Since whole body aerobic exercise training improves breathing endurance and inspiratory muscle strength, we hypothesized that endurance-trained individuals would demonstrate a blunted inspiratory muscle metaboreflex in comparison to sedentary individuals. We studied 9 runners (23±0.7 yrs; maximal oxygen uptake [O max]=53±4ml.kg-1.min-1) and 9 sedentary healthy volunteers (24±0.7years; O max=37±2ml.kg-1.min-1). The inspiratory muscle metaboreflex was induced by breathing against an inspiratory load of 60% of maximal inspiratory pressure (MIP), with prolonged duty cycle. Arterial pressure, popliteal blood flow, and heart rate were measured throughout the protocol. Loaded breathing to task failure increased mean arterial pressure in both sedentary and endurance-trained individuals (96±3 to 100±4mmHg and 101±3 to 110±5mmHg). Popliteal blood flow decreased in sedentary but not in trained individuals (0.179±0.01 to 0.141±0.01cm/s, and 0.211±0.02 to 0.214±0.02cm/s). Similarly, popliteal vascular resistance increased in sedentary but not in trained individuals (559±35 to 757±56mmHgs/cm, and 528±69 to 558±64mmHgs/cm). These data demonstrate that endurance-trained individuals have an attenuated inspiratory muscle metaboreflex.
Authors:
Carine C Callegaro; Jorge P Ribeiro; Can Ozan Tan; J Andrew Taylor
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-4
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  -     ISSN:  1878-1519     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier B.V.
Affiliation:
Cardiovascular Research Laboratory, Spaulding Rehabilitation Hospital, and Department of Physical Medicine and Rehabilitation, Harvard Medical School,, Boston, Massachusetts, USA; Exercise Pathophysiology Research Laboratory, Cardiology Division, Hospital de Clínicas Porto Alegre.
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