Document Detail


Attenuated exercise induced hyperaemia with age: mechanistic insight from passive limb movement.
MedLine Citation:
PMID:  20876201     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influence of age on the central and peripheral contributors to exercise-induced hyperaemia is unclear. Utilizing a reductionist approach, we compared the peripheral and central haemodynamic responses to passive limb movement (exercise without an increase in metabolism) in 11 old (71 ± 9 years of age S.D.) and 11 young (24 ± 2 years of age) healthy subjects. Cardiac output (CO), heart rate (HR), stroke volume (SV), mean arterial pressure (MAP), and femoral blood flow of the passively moved and control legs were evaluated second-by-second during 2 min of passive knee extension at a rate of 1 Hz. Compared to the young, the old group exhibited a significantly attenuated increase in HR (7 ± 4% vs. 13 ± 7% S.D.), CO (10 ± 6% vs. 18 ± 8%) and femoral blood flow in the passively moved (123 ± 55% vs. 194 ± 57%) and control legs (47 ± 43% vs. 77 ± 96%). In addition, the change in vascular conductance in the passively moving limb was also significantly attenuated in the old (2.4 ± 1.2 ml min(-1) mmHg(-1)) compared to the young (4.3 ± 1.7 ml min(-1) mmHg(-1)). In both groups all main central and peripheral changes that occurred at the onset of passive knee extension were transient, lasting only 45 s. In a paradigm where metabolism does not play a role, these data reveal that both central and peripheral haemodynamic mechanisms are likely to be responsible for the 30% reduction in exercise-induced hyperaemia with age.
Authors:
John McDaniel; Melissa A Hayman; Steve Ives; Anette S Fjeldstad; Joel D Trinity; D Walter Wray; Russell S Richardson
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2010-09-27
Journal Detail:
Title:  The Journal of physiology     Volume:  588     ISSN:  1469-7793     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-16     Completed Date:  2011-09-30     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  4507-17     Citation Subset:  IM    
Affiliation:
George E. Whalen VA Medical Center, Salt Lake City, Utah 84148, USA. John.McDaniel@utah.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Aging / physiology*
Blood Flow Velocity / physiology
Exercise / physiology*
Extremities / blood supply,  physiology
Humans
Hyperemia / physiopathology*
Leg / blood supply,  physiology*
Male
Motion Therapy, Continuous Passive* / methods
Movement / physiology*
Young Adult
Grant Support
ID/Acronym/Agency:
P01 HL 109183/HL/NHLBI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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