| Attenuated Cardiovascular Response to Sympathetic System Activation during Exercise in Patients with Dialysis-Induced Hypotension. | |
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MedLine Citation:
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PMID: 21546765 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: We wished to investigate potential causes of dialysis-induced hypotension (DIH), including the attenuated cardiovascular response to sympathetic system activation during exercise and myocardial dysfunction. Methods: This study included 26 end-stage renal disease (ESRD) patients with DIH, 30 ESRD patients without DIH (Non-DIH), and 30 control subjects. Each patient was evaluated with echocardiography and a symptom-limited treadmill stress test. The chronotropic index (CRI), heart rate recovery (HRR), systolic blood pressure response to exercise (SBP response), and tissue Doppler systolic myocardial velocities were calculated. Results: The HRR and velocities were reduced in dialysis patients compared to controls; however, they were similar in patients with and without DIH. Patients with DIH had the lowest CRI compared to theNon-DIH group (0.62 ± 0.15 vs. 0.73 ± 0.17, p = 0.020) and controls (0.62 ± 0.15 vs. 0.86 ± 0.11, p < 0.001). Similarly, patients with DIH had the lowest SBP response values compared to the Non-DIH (34.88 ± 15.01 vs. 55.67 ± 25.42, p = 0.002) and controls (34.88 ± 15.01 vs. 59.70 ± 23.04, p < 0.001). Conclusion: Patients with DIH have inadequate sympathetic activity of the cardiovascular system during exercise and impaired left ventricular systolic function. Both factors could contribute to the development of hypotension during hemodialysis. |
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Authors:
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Hakan Fotbolcu; Dursun Duman; Sebahat Alısır Ecder; Vecih Oduncu; Cihan Cevik; Kursat Tigen; Gokce Sirin; Emre Ozker; Burak Kıran; Yelda Basaran |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-05 |
Journal Detail:
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Title: American journal of nephrology Volume: 33 ISSN: 1421-9670 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109361 Medline TA: Am J Nephrol Country: - |
Other Details:
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Languages: ENG Pagination: 491-498 Citation Subset: - |
Copyright Information:
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Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
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Division of Cardiology, Goztepe Medical Park Hospital, Istanbul, Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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