Document Detail

Attenuated ANF response to exercise in athletes with exercise-induced hypoxemia.
MedLine Citation:
PMID:  15162243     Owner:  NLM     Status:  MEDLINE    
Some highly trained endurance athletes develop an exercise-induced hypoxemia (EIH) at least partially due to a hemodynamic factor with a potential stress failure on pulmonary capillaries. Atrial natriuretic factor (ANF) is a pulmonary vasodilatator and its release during exercise could be reduced with endurance training. We hypothesized that athletes exhibiting EIH, who have a greater training volume than non-EIH athletes, have a reduced ANF release during exercise explaining the pathophysiology of EIH. Ten highly trained EIH-athletes (HT-EIH), ten without EIH (HT-nEIH), and nine untrained (UT) males performed incremental exercise to exhaustion. No between group differences occurred in resting ANF plasma levels. In contrast to HT-nEIH and UT (p < 0.05), HT-EIH showed a smaller increase in ANF concentration between rest and maximal exercise (HT-EIH: 8.12 +/- 0.69 vs. 14.1 +/- 1.86 pmol x l (-1); HT-nEIH: 10.46 +/- 1 vs. 18.7 +/- 1.8 pmol x l (-1); UT: 6.23 +/- 0.95 vs. 20.38 +/- 2.79 pmol x l (-1)). During the recovery, ANF levels decreased significantly in HT-nEIH and UT groups (p < 0.05). Electrolyte values increased in all groups during exercise but were higher in both trained groups. In conclusion, this study suggested that ANF response to exercise may be important for exercise-induced hypoxemia.
F Durand; P Mucci; M Hayot; I Couret; A Bonnardet; Ch Préfaut
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of sports medicine     Volume:  25     ISSN:  0172-4622     ISO Abbreviation:  Int J Sports Med     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-26     Completed Date:  2004-09-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  252-6     Citation Subset:  IM    
Laboratoire Sport, Santé, Altitude, Département STAPS, Font-Romeu, France.
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MeSH Terms
Anoxia / blood,  physiopathology*
Atrial Natriuretic Factor / blood,  physiology*
Blood Proteins / analysis
Exercise / physiology*
Heart Rate / physiology
Osmolar Concentration
Physical Endurance / physiology*
Potassium / blood
Reference Values
Rest / physiology
Sodium / blood
Reg. No./Substance:
0/Blood Proteins; 7440-09-7/Potassium; 7440-23-5/Sodium; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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