Document Detail

Attentional response at eight weeks in prenatally drug-exposed and preterm infants.
MedLine Citation:
PMID:  10492387     Owner:  NLM     Status:  MEDLINE    
To evaluate the effect of prenatal polydrug exposure on infant attention, 105 8-week-old African-American infants were presented a series of stimuli and their heart rates (HRs) were recorded. Infants were identified postnatally based on mothers' substance use. Four groups were tested: 1) preterm drug-exposed infants (n = 25); 2) full-term, drug-exposed (n = 32); 3) preterm nonexposed (n = 22); and 4) full-term, nonexposed (n = 26). Preterm infants' ages were corrected. Infant's baseline HRs were recorded and then stimuli presented in the following order: auditory (rattle), visual (red ring), and social (examiner's face and voice). There were no HR differences at baseline or in auditory or visual conditions. However, significant differences (F(2, 103) = 6.54, p < 0.01) were seen in response to social stimuli. Drug-exposed infants showed an acceleratory HR indicating distress or arousal and control infants showed a deceleratory response indicating focused attention and there was an interaction due to greater HR response in preterms. Hierarchical regression indicated cocaine (R2 = 0.034, p < 0.05) but not other drug use and instability in parenting (R2 = 0.137, p < 0.001) accounted for the observed differences.
C D Coles; K A Bard; K A Platzman; M E Lynch
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurotoxicology and teratology     Volume:  21     ISSN:  0892-0362     ISO Abbreviation:  Neurotoxicol Teratol     Publication Date:    1999 Sep-Oct
Date Detail:
Created Date:  1999-10-22     Completed Date:  1999-10-22     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  8709538     Medline TA:  Neurotoxicol Teratol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  527-37     Citation Subset:  IM    
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
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MeSH Terms
Analysis of Variance
Attention / drug effects*
Birth Weight / drug effects
Body Height / drug effects
Body Weight / drug effects
Child Development / drug effects
Cocaine / adverse effects*
Educational Status
Follow-Up Studies
Heart Rate / drug effects
Infant, Newborn
Infant, Premature
Maternal Age
Prenatal Exposure Delayed Effects*
Social Class
Grant Support
Reg. No./Substance:

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