Document Detail


Attention strongly increases oxygen metabolic response to stimulus in primary visual cortex.
MedLine Citation:
PMID:  21839179     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Top-down attention enhances neural processing, but its effect on metabolic activity in primary visual cortex (V1) is unclear. Combined blood flow and oxygenation measurements provide the best tool for investigating modulations of oxidative metabolism. We measured the human V1 response to a peripheral low contrast stimulus using fMRI and found a larger fractional modulation of blood flow with attention compared to the blood oxygenation level dependent (BOLD) response, thus indicating a much larger modulation of oxygen metabolism than was previously thought. These findings point to different aspects of neural activity driving flow and metabolic changes to different degrees. We propose that V1 flow is driven strongly but not exclusively by the initial sensory-driven neural activity, which dominates the response in the unattended condition, while V1 oxygen metabolism is driven strongly by the overall neural activity, which is modulated by top-down signals related to attention.
Authors:
Farshad Moradi; Giedrius T Buračas; Richard B Buxton
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-07-31
Journal Detail:
Title:  NeuroImage     Volume:  59     ISSN:  1095-9572     ISO Abbreviation:  Neuroimage     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-10-17     Completed Date:  2012-02-13     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  9215515     Medline TA:  Neuroimage     Country:  United States    
Other Details:
Languages:  eng     Pagination:  601-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult
Attention / physiology*
Brain Mapping
Cerebrovascular Circulation / physiology*
Female
Humans
Magnetic Resonance Imaging
Male
Oxygen / blood*
Spin Labels
Visual Cortex / blood supply*,  metabolism
Young Adult
Grant Support
ID/Acronym/Agency:
NS-36722/NS/NINDS NIH HHS; R01 NS036722/NS/NINDS NIH HHS; R01 NS036722-13/NS/NINDS NIH HHS; T32 EB005970/EB/NIBIB NIH HHS; T32-EB005970/EB/NIBIB NIH HHS
Chemical
Reg. No./Substance:
0/Spin Labels; S88TT14065/Oxygen
Comments/Corrections

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