Document Detail

Attention deficit/hyperactivity disorder: burden of the disease according to subtypes in recently diagnosed children
MedLine Citation:
PMID:  18830848     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Attention-Deficit/Hyperactivity Disorder (ADHD) is associated with deterioration of several dimensions of quality of life (QoL) and with the development of comorbid psychiatric disorders. The objective of the present study is to evaluate the burden of illness of ADHD subtypes in untreated newly diagnosed children in Spain. METHODS: We recruited 124 children (80 combined, 25 inattentive and 19 hyperactive-impulsive subtype) aged 6-12 years with untreated newly diagnosed Diagnostic and Statistical Manual of Mental Disorders, 4th edition DSM-IV) ADHD. We collected socio-demographic, clinical (Attention-Deficit/Hyperactivity Disorder Rating Scale ADHD-RS], Conner's Parent Rating Scale-Revised: Short Form [CPRS:R-S], Clinical Global Impression-Severity [CGI-S], Kiddie Schedule for Affective Disorders and Schizophrenia for School Aged Children-Present and Lifetime Version [K-SADS-PL], intelligence Quotient [IQ]), Quality of Life (QoL), Child Health Questionnaire-Parent Form 50 CHQ-PF50), academic performance and health care resources utilization data. We investigated the correlations between ADHD symptom severity and QoL, academic performance and time from onset of symptoms to diagnosis. RESULTS: QoL of children with combined-type ADHD was rated as significantly worse in patients with predominance of hyperactivity/impulsivity for most of the domains. Inattentive-type children also had worse ratings than patients with hyperactivity/impulsivity predominance in most of the domains. The ADHD Index of Conner's Parent Rating Scale-Revised: Short Form (CPRS-R:S) was significantly lower in hyperactive/impulsive patients. We found no differences across subtypes in IQ, academic performance and health care resources utilization. Higher ADHD symptom severity was associated to poor QoL. CONCLUSIONS: Combined and inattentive subtypes are associated with greater disorder severity, more comorbid psychiatric disorders, and worse QoL than the subtype with hyperactivity/impulsivity predominance.
R Escobar; A Hervas; C Soutullo; M J Mardomingo; A Uruñuela; I Gilaberte
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Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Actas españolas de psiquiatría     Volume:  36     ISSN:  1139-9287     ISO Abbreviation:  Actas Esp Psiquiatr     Publication Date:    2008 Sep-Oct
Date Detail:
Created Date:  2008-10-02     Completed Date:  2009-03-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886502     Medline TA:  Actas Esp Psiquiatr     Country:  Spain    
Other Details:
Languages:  spa     Pagination:  285-94     Citation Subset:  IM    
Lilly Research Laboratories, Alcobendas (Madrid).
Vernacular Title:
Trastorno por déficit de atención/hiperactividad: impacto de la enfermedad de acuerdo al subtipo en niños con diagnóstico reciente.
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MeSH Terms
Attention Deficit Disorder with Hyperactivity / classification*,  diagnosis
Case-Control Studies
Cost of Illness*
Prospective Studies
Quality of Life

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