Document Detail

Attention deficits in bipolar disorder: a comparison based on the Continuous Performance Test.
MedLine Citation:
PMID:  15823428     Owner:  NLM     Status:  MEDLINE    
Although attentional deficits measured by Continuous Performance Tests (CPTs) have been observed in patients with bipolar disorder, their relationship with clinical state is not well understood. The identical pairs Continuous Performance Test (CPT-IP) shows particular promise as a measure sensitive to trait abnormalities in attentional function. In this study, the CPT-IP was administered to 27 patients with bipolar disorder (22 type I, 5 type II) and 25 demographically matched healthy comparison subjects, in order to assess the presence and nature of attentional deficits as a function of mood symptoms. Results showed significantly impaired CPT performance in bipolar patients compared with healthy subjects. Patients made fewer hits (p < 0.01), were slower to respond (p < 0.007), and had poorer discrimination (p < 0.05) and bias (p < 0.006) than comparison subjects. Severity of mania and depression was not correlated with any of the CPT measures. Our findings suggest that attentional dysfunction may be a trait deficit associated with bipolar illness. However, within-subjects longitudinal studies examining fluctuations in performance over time are needed.
Pablo Najt; David Glahn; Carrie E Bearden; John P Hatch; E Serap Monkul; Simerjit Kaur; Veronica Villarreal; Charles Bowden; Jair C Soares
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.     Date:  2005-01-20
Journal Detail:
Title:  Neuroscience letters     Volume:  379     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-12     Completed Date:  2005-06-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  122-6     Citation Subset:  IM    
South Texas Veterans Health Care System, Audie L. Murphy Division, San Antonio, TX, USA.
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MeSH Terms
Analysis of Variance
Attention Deficit Disorder with Hyperactivity / physiopathology*
Bipolar Disorder / physiopathology*
Case-Control Studies
Discrimination (Psychology) / physiology
Intelligence / physiology
Middle Aged
Neuropsychological Tests / statistics & numerical data*
Psychiatric Status Rating Scales
Reaction Time / physiology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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