Document Detail

Attack from both ends: mRNA degradation in the crenarchaeon Sulfolobus solfataricus.
MedLine Citation:
PMID:  23356315     Owner:  NLM     Status:  In-Data-Review    
RNA stability control and degradation are employed by cells to control gene expression and to adjust the level of protein synthesis in response to physiological needs. In all domains of life, mRNA decay can commence in the 5'-3' as well as in the 3'-5'-direction. Consequently, mechanisms are in place conferring protection on mRNAs at both ends. Upon deprotection, dedicated enzymes/enzyme complexes access either end and trigger 5'-3' or 3'-5'-directional decay. In the present paper, we first briefly review the general mRNA decay pathways in Bacteria and Eukarya, and then focus on 5'-3' and 3'-5'-directional decay in the crenarchaeon Sulfolobus solfataricus, which is executed by a RNase J-like ribonuclease and the exosome complex respectively. In addition, we describe mechanisms that stabilize mRNAs at the 5'- as well as at the 3'-end.
Elena Evguenieva-Hackenberg; Udo Bläsi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical Society transactions     Volume:  41     ISSN:  1470-8752     ISO Abbreviation:  Biochem. Soc. Trans.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506897     Medline TA:  Biochem Soc Trans     Country:  England    
Other Details:
Languages:  eng     Pagination:  379-83     Citation Subset:  IM    
*Institute of Microbiology and Molecular Biology, University of Giessen, Heinrich-Buff-Ring 26-32, 35392 Giessen, Germany.
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