Document Detail

Atropine fails to block the overconsumption of sugar solutions by hypothalamic hyperphagic rats.
MedLine Citation:
PMID:  7031103     Owner:  NLM     Status:  MEDLINE    
Adult female rats given bilateral parasagittal knife cuts in the medial hypothalamus (VMH group) were hyperphagic and became obese on a chow diet, compared with sham-operated controls. The VMH rats also overconsumed, relative to controls, sucrose and glucose solutions during 30 min/day tests. Pretreating the VMH and control rats with atropine methyl nitrate (1.0, 5.0, or 10.0 mg/kg) reduced their intake of the sugar solutions in three out of five experiments, and in all experiments it suppressed their 24-hr chow intake. However, the VMH rats continued to drink more of the sugar solutions than did the controls after all atropine treatments, and in three out of four experiments their hyperphagia on the chow diet was not blocked by the atropine. The results do not support the hypothesis that vagally stimulated insulin release or other cholinergically mediated cephalic responses of digestion are essential for the expression of hypothalamic hyperphagia and finickiness.
A Sclafani; S Xenakis
Related Documents :
16222053 - Increased a-ring reduction of glucocorticoids in obese zucker rats: effects of insulin ...
16678223 - Neonatal capsaicin causes compensatory adjustments to energy homeostasis in rats.
11722703 - Differential neuropeptide responses to starvation with ageing.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of comparative and physiological psychology     Volume:  95     ISSN:  0021-9940     ISO Abbreviation:  J Comp Physiol Psychol     Publication Date:  1981 Oct 
Date Detail:
Created Date:  1982-02-12     Completed Date:  1982-02-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0414612     Medline TA:  J Comp Physiol Psychol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  708-19     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Atropine / pharmacology*
Dose-Response Relationship, Drug
Drinking / drug effects*
Eating / drug effects*
Hypothalamus / physiology*
Hypothalamus, Middle / physiology*
Insulin / blood
Rats, Inbred Strains
Sucrose / administration & dosage
Taste / drug effects*,  physiology
Vagus Nerve / physiology
Grant Support
Reg. No./Substance:
11061-68-0/Insulin; 51-55-8/Atropine; 57-50-1/Sucrose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A computer program for distinctive feature analysis.
Next Document:  Vagotomy blocks hypothalamic hyperphagia in rats on a chow diet and sucrose solution, but not on a p...