Document Detail


Atropine fails to block the overconsumption of sugar solutions by hypothalamic hyperphagic rats.
MedLine Citation:
PMID:  7031103     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adult female rats given bilateral parasagittal knife cuts in the medial hypothalamus (VMH group) were hyperphagic and became obese on a chow diet, compared with sham-operated controls. The VMH rats also overconsumed, relative to controls, sucrose and glucose solutions during 30 min/day tests. Pretreating the VMH and control rats with atropine methyl nitrate (1.0, 5.0, or 10.0 mg/kg) reduced their intake of the sugar solutions in three out of five experiments, and in all experiments it suppressed their 24-hr chow intake. However, the VMH rats continued to drink more of the sugar solutions than did the controls after all atropine treatments, and in three out of four experiments their hyperphagia on the chow diet was not blocked by the atropine. The results do not support the hypothesis that vagally stimulated insulin release or other cholinergically mediated cephalic responses of digestion are essential for the expression of hypothalamic hyperphagia and finickiness.
Authors:
A Sclafani; S Xenakis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of comparative and physiological psychology     Volume:  95     ISSN:  0021-9940     ISO Abbreviation:  J Comp Physiol Psychol     Publication Date:  1981 Oct 
Date Detail:
Created Date:  1982-02-12     Completed Date:  1982-02-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0414612     Medline TA:  J Comp Physiol Psychol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  708-19     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Atropine / pharmacology*
Dose-Response Relationship, Drug
Drinking / drug effects*
Eating / drug effects*
Female
Hypothalamus / physiology*
Hypothalamus, Middle / physiology*
Insulin / blood
Rats
Rats, Inbred Strains
Sucrose / administration & dosage
Taste / drug effects*,  physiology
Vagus Nerve / physiology
Grant Support
ID/Acronym/Agency:
AM 23064/AM/NIADDK NIH HHS; MH-07299/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
11061-68-0/Insulin; 51-55-8/Atropine; 57-50-1/Sucrose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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