| Atrophy patterns in histologic vs clinical groupings of frontotemporal lobar degeneration. | |
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MedLine Citation:
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PMID: 19433738 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Predictable patterns of atrophy are associated with the clinical subtypes of frontotemporal dementia (FTD): behavioral variant (bvFTD), semantic dementia (SEMD), and progressive nonfluent aphasia (PNFA). Some studies of pathologic subtypes have also suggested specific atrophy patterns; however, results are inconsistent. Our aim was to test the hypothesis that clinical, but not pathologic, classification (FTD with ubiquitin inclusions [FTD-U] and FTD with tau inclusions [FTD-T]) is associated with predictable patterns of regional atrophy. METHODS: Magnetic resonance scans of nine FTD-U and six FTD-T patients (histologically confirmed) were compared with 25 controls using voxel-based morphometry (VBM). Analyses were conducted with the patient group classified according to histologic or clinical variant. Additionally, three Alzheimer pathology patients who had the syndrome of SEMD in life (FTD-A) were analyzed. RESULTS: The VBM studies in clinical variants confirmed established patterns of atrophy (SEMD, rostral temporal; bvFTD, mesial frontal; PNFA, left insula). FTD-U and FTD-T VBM results were very similar, showing severe atrophy in the temporal poles, mesial frontal lobe, and insulae. A conjunction analysis confirmed this similarity. Subgroup analysis found that SEMD associated with either FTD-T or FTD-U was associated with similar rostral temporal atrophy; however, FTD-A had a qualitatively different pattern of left hippocampal atrophy. CONCLUSIONS: While there is predictable atrophy for clinical variants of frontotemporal dementia (FTD), histologic FTD variants show no noticeable differences. Reports of specific atrophy profiles are likely the result of idiosyncrasies in small groups. Semantic dementia associated with Alzheimer pathology, however, presented a distinct atrophy pattern. |
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Authors:
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J M S Pereira; G B Williams; J Acosta-Cabronero; G Pengas; M G Spillantini; J H Xuereb; J R Hodges; P J Nestor |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurology Volume: 72 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-12 Completed Date: 2009-06-30 Revised Date: 2010-09-27 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
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Languages: eng Pagination: 1653-60 Citation Subset: AIM; IM |
Affiliation:
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Department of Clinical Neurosciences, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aphasia, Primary Progressive / pathology, physiopathology Atrophy / classification, etiology, pathology* Brain Mapping / methods Cerebral Cortex / pathology*, physiopathology Dementia / classification, pathology*, physiopathology Disease Progression Female Frontal Lobe / pathology, physiopathology Functional Laterality / physiology Hippocampus / pathology, physiopathology Humans Image Processing, Computer-Assisted / methods Inclusion Bodies / pathology Magnetic Resonance Imaging / methods Male Middle Aged Severity of Illness Index Temporal Lobe / pathology, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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//Medical Research Council |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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