Document Detail


Atrophy of mesial structures in patients with temporal lobe epilepsy: cause or consequence of repeated seizures?
MedLine Citation:
PMID:  8250528     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied 70 epileptic patients by using magnetic resonance imaging volumetric measurements of amygdala (AM) and hippocampal formation (HF). Fifty patients presented with intractable temporal lobe epilepsy (TLE), 10 patients had focal extratemporal lobe epilepsy, and 10 had generalized epilepsy. In 91% of the 45 TLE patients without foreign tissue lesions, there was significant smallness of the AM and/or HF coinciding with the side of electroencephalographic seizure onset. No significant smallness or asymmetry was demonstrated in patients with focal extratemporal or generalized epilepsy. We performed a linear regression analysis, plotting the number of years of recurrent seizures and the estimated seizure frequency against the volumes of the AM and HF. There was no correlation between either of these two parameters and AM or HF volume (p > 0.9). There was also no correlation between the patient's age and volumetric measurements of AM or HF, nor did these measurements correlate with the occurrence of generalized seizures. On the other hand, patients with antecedent prolonged febrile convulsions in early childhood had significantly smaller AM and HF, compared with those without such a history (p < 0.001). The findings indicate that repeated seizures or longer duration of epilepsy do not cause increased atrophy of AM or HF that is measurable by volumetric magnetic resonance imaging.
Authors:
F Cendes; F Andermann; P Gloor; I Lopes-Cendes; E Andermann; D Melanson; M Jones-Gotman; Y Robitaille; A Evans; T Peters
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of neurology     Volume:  34     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-01-04     Completed Date:  1994-01-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  795-801     Citation Subset:  IM    
Affiliation:
Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Amygdala / pathology*
Analysis of Variance
Atrophy / physiopathology
Child
Epilepsies, Partial / pathology
Epilepsy, Generalized / pathology
Epilepsy, Temporal Lobe / pathology*,  physiopathology
Female
Hippocampus / pathology*
Humans
Linear Models
Magnetic Resonance Imaging
Male
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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