Document Detail

Atrophic vaginitis versus invasive squamous cell carcinoma on ThinPrep cytology: can the background be reliably distinguished?
MedLine Citation:
PMID:  12451567     Owner:  NLM     Status:  MEDLINE    
The presence of pronounced squamous epithelial atrophy/atrophic vaginitis on cervicovaginal preparations can present diagnostic difficulties, particularly in the presence of a granular background. The purpose of this study was to compare and contrast the background material present on ThinPrep cytology in cases of atrophic vaginitis and invasive squamous cell carcinoma (SCC). Thirty-three cases of atrophic vaginitis showed a heavy background of granular material containing acute inflammatory cells, apoptotic bodies, and fresh/crenated red blood cells. These findings were indistinguishable from those present in five cases of invasive SCC. The only significant finding was the presence of malignant squamous epithelial cells in the latter. Since the background material in pronounced squamous epithelial atrophy/atrophic vaginitis mimics that present in invasive SCC on ThinPrep cytology, close attention must be paid to the cells present on the slide in order to render an accurate diagnosis.
Suzanne M Selvaggi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Diagnostic cytopathology     Volume:  27     ISSN:  8755-1039     ISO Abbreviation:  Diagn. Cytopathol.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-11-26     Completed Date:  2003-05-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8506895     Medline TA:  Diagn Cytopathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  362-4     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Wiley-Liss, Inc.
Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Madison, Wisconsin 53792-2472, USA.
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MeSH Terms
Carcinoma, Squamous Cell / pathology*
Diagnosis, Differential
Disease Susceptibility / pathology
Epithelial Cells / pathology
Middle Aged
Neoplasm Invasiveness / pathology
Reproducibility of Results
Uterine Cervical Neoplasms / pathology*
Vaginal Smears / methods*
Vaginitis / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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