Document Detail

Atrophic gastritis in Sjögren's syndrome. Morphologic, biochemical, and immunologic findings.
MedLine Citation:
PMID:  3885959     Owner:  NLM     Status:  MEDLINE    
Gastric studies were carried out in 16 patients with well-documented Sjögren's syndrome (SS), 43 matched rheumatic disease patients without SS, and 7 patients with chronic atrophic gastritis not associated with SS. Chronic atrophic gastritis was a much more common finding in the SS patients than in the rheumatic disease control patients. Significant hypopepsinogenemia was present in 11 of 16 SS patients. In 6 patients this was combined with hypergastrinemia, a combination highly specific for chronic atrophic gastritis. The lowest pepsinogen levels were seen in patients with primary SS associated with high levels of SS-B antibody. On a histologic and biochemical basis, it was not possible to distinguish the gastric findings in primary SS from those in secondary SS, nor to distinguish chronic atrophic gastritis associated with SS from that not associated with SS. We conclude that chronic atrophic gastritis is a prominent feature in SS and that the severity of the gastritis appears to correlate with some serologic parameters of SS.
C P Maury; T Törnroth; A M Teppo
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  28     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-05-16     Completed Date:  1985-05-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  388-94     Citation Subset:  AIM; IM    
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MeSH Terms
Antibodies / analysis
Carbohydrates / analysis
Gastric Mucosa / analysis,  pathology
Gastritis / pathology*
Gastritis, Atrophic / immunology,  metabolism,  pathology*
Middle Aged
Pepsinogens / blood
Prospective Studies
Rheumatic Diseases / immunology,  metabolism,  pathology
Sjogren's Syndrome / immunology,  metabolism,  pathology*
beta 2-Microglobulin / analysis
Reg. No./Substance:
0/Antibodies; 0/Carbohydrates; 0/Pepsinogens; 0/beta 2-Microglobulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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