Document Detail

Atromentin and leucomelone, the first inhibitors specific to enoyl-ACP reductase (FabK) of Streptococcus pneumoniae.
MedLine Citation:
PMID:  17323650     Owner:  NLM     Status:  MEDLINE    
Two potent inhibitors of FabK, the enoyl-acyl carrier protein (ACP) reductase of Streptococcus pneumoniae, were isolated from the solid state fermentation of an unidentified fungus F010248. Their structures were identified to be atromentin and leucomelone by various spectral analysis. Atromentin and leucomelone inhibited the FabK with IC50 values of 0.24 and 1.57 microM, respectively, while did not inhibit FabI, the enoyl-ACP reductase of either Escherichia coli or Staphylococcus aureus, even at 200 microM. Atromentin and leucomelone are the first inhibitors specific to the enoyl-ACP reductase (FabK) of Streptococcus pneumoniae.
Chang-Ji Zheng; Mi-Jin Sohn; Won-Gon Kim
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  59     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-02-27     Completed Date:  2007-03-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  808-12     Citation Subset:  IM    
Functional Metabolomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Yusong, Daejeon 305-806, Republic of Korea.
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MeSH Terms
Benzoquinones / isolation & purification*,  pharmacology
Catechols / isolation & purification*,  pharmacology
Dose-Response Relationship, Drug
Enoyl-(Acyl-Carrier-Protein) Reductase (NADH) / antagonists & inhibitors*
Enzyme Inhibitors / isolation & purification*,  pharmacology
Fungi / metabolism*
Phenols / isolation & purification*,  pharmacology
Streptococcus pneumoniae / enzymology*
Reg. No./Substance:
0/Benzoquinones; 0/Catechols; 0/Enzyme Inhibitors; 0/Phenols; 0/atromentin; 0/leucomelone; EC Reductase (NADH)

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