Document Detail


Atrioventricular valve annulus velocity and acceleration during global hypoxia in newborn pigs - assessment of myocardial function.
MedLine Citation:
PMID:  19713716     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Global hypoxia may affect regions of the neonatal heart during systole and diastole differently. OBJECTIVE: In the first study, the aim was to assess longitudinal myocardial function in newborn pigs during global hypoxia and recovery. In the second study, invasive hemodynamic data were evaluated and compared with tissue velocities and acceleration. METHODS: Myocardial Doppler measurements of velocity and acceleration in the atrioventricular valve annuli during global hypoxia were made. Results: In the first experiment, systolic velocity (S), early diastolic velocity (E') and peak systolic acceleration (pSac) decreased during hypoxia. S, pSac and E'(mva) (mitral valve annulus) recovered after reoxygenation, while E'(septal) and E'(tva) (tricuspid valve annulus) did not. Isovolumic acceleration (IVA) did not reflect systolic dysfunction. In the second experiment, S(mva) and pSac(mva) declined during hypoxia similarly to maximum dP/dT. E'(mva) and E'(tva) were correlated with tau and both changed parallel to minimum dP/dT. In the TVA maximum dP/dT and pSac(tva) did not change, while S(tva) declined. By correcting for heart rate the pattern of alteration in S and pSac became comparable to the changes in E'. CONCLUSION: Tissue Doppler velocity in systole, diastole and acceleration during rapid ejection reflect hemodynamic changes in the neonatal myocardium during global hypoxia and recovery. S and pSac reflect systolic function, while E' correlates with tau and mirrors diastolic function.
Authors:
Hans Henrik Odland; Grete A B Kro; Thor Edvardsen; Erik Thaulow; Ola Didrik Saugstad
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-28
Journal Detail:
Title:  Neonatology     Volume:  97     ISSN:  1661-7819     ISO Abbreviation:  Neonatology     Publication Date:  2010  
Date Detail:
Created Date:  2010-02-05     Completed Date:  2010-04-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101286577     Medline TA:  Neonatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  100-7     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Affiliation:
Department of Pediatric Research, Rikshospitalet University Hospital, Oslo, Norway. h.h.odland@medisin.uio.no
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Anoxia / physiopathology*,  ultrasonography
Diastole / physiology
Disease Models, Animal
Echocardiography, Doppler
Heart Rate / physiology
Linear Models
Mitral Valve / physiopathology*,  ultrasonography
Myocardial Contraction / physiology*
Recovery of Function / physiology
Stroke Volume / physiology
Swine
Systole / physiology
Tricuspid Valve / physiopathology*,  ultrasonography
Ventricular Pressure / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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