Document Detail


Atrioventricular heart block and syncope coincident with diagnosis of systemic lupus erythematosus.
MedLine Citation:
PMID:  23916739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We describe a 59-year-old woman with cardiac conduction abnormalities caused by lupus-induced myocardial damage. She had a history of arthralgias and antinuclear antibodies but no clinical history of systemic lupus erythematosus. She presented with syncope and Mobitz type II second-degree atrioventricular block. Anti-double-stranded DNA antibodies developed coincident with the identification of heart block. Cardiac magnetic resonance imaging showed late enhancing foci of gadolinium uptake that anatomically correlated with her conduction abnormalities. We conclude that her conduction disease represents an early and structural cardiac manifestation of systemic lupus erythematosus that is unusual in its presentation at the time of initial diagnosis.
Authors:
Micah T Prochaska; Paul A Bergl; Amit R Patel; Joshua D Moss; Stephen L Archer
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural     Date:  2013-08-02
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  29     ISSN:  1916-7075     ISO Abbreviation:  Can J Cardiol     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-09-30     Completed Date:  2013-11-26     Revised Date:  2014-10-09    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1330.e5-1330.e7     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Antinuclear / analysis
Atrioventricular Block / diagnosis,  etiology*,  physiopathology
Diagnosis, Differential
Electrocardiography*
Female
Heart Rate
Humans
Lupus Erythematosus, Systemic / complications*,  diagnosis,  immunology
Magnetic Resonance Imaging, Cine / methods*
Middle Aged
Syncope / diagnosis,  etiology*,  physiopathology
Grant Support
ID/Acronym/Agency:
1RC1HL099462-01/HL/NHLBI NIH HHS; R01 HL071115/HL/NHLBI NIH HHS; R01 HL107949/HL/NHLBI NIH HHS; R01 HL113003/HL/NHLBI NIH HHS; R01-HL071115/HL/NHLBI NIH HHS; R01-HL091475/HL/NHLBI NIH HHS; RC1 HL099462/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Antinuclear
Comments/Corrections

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