| Atriopeptin III does not alter cardiac performance in rats. | |
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MedLine Citation:
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PMID: 2945855 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of atriopeptin III (APIII) on systemic haemodynamics were examined in 12 anaesthetized rats. Five minutes following intravenous injection (i.v.) of 10 micrograms/kg APIII, cardiac output CO, measured by electromagnetic flowmetry, stroke volume and mean arterial pressure (MAP) decreased by 14, 13 and 8% (P less than 0.05), respectively, and total peripheral resistance (TPR) increased by 10% (P less than 0.05). Heart rate (HR) and left ventricular end-diastolic pressure (LVEDP) did not change. In order to examine cardiac performance, whole blood was infused into three groups of 12 rats each receiving either no injection, APIII (10 micrograms/kg i.v.) or APIII (10 micrograms/kg i.v.) plus a continuous infusion of phenylephrine to increase MAP to pre-injection levels. Cardiac performance curves did not differ among the three groups. These data indicate that the immediate decreases in MAP and CO produced in rats by a maximum natriuretic bolus dose of APIII were not mediated by a negative myocardial inotropic effect. |
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Authors:
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T Natsume; M B Kardon; N C Trippodo; A Januszewicz; B L Pegram; E D Frohlich |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of hypertension Volume: 4 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 1986 Aug |
Date Detail:
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Created Date: 1986-12-10 Completed Date: 1986-12-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 477-80 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atrial Natriuretic Factor / pharmacology* Blood Pressure / drug effects Cardiac Output / drug effects Heart Rate / drug effects Hemodynamics / drug effects* Male Rats Rats, Inbred Strains Stroke Volume / drug effects Vascular Resistance / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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HL-29952/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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