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Atrichia with papular lesions.
MedLine Citation:
PMID:  22223974     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Atrichia with papular lesions (APL) is a rare autosomal recessive form of irreversible alopecia with onset at few months of age with papular keratin cysts over the body. It is associated with mutation in the Zinc finger domain of the human hairless gene on chromosome region 8p12. An eleven-year-old male presented with extensive alopecia starting at six months of age refractory to the treatment along with keratotic papules on the face and trunk. Biopsy from a papule showed mid-dermal keratin cysts and from the scalp showed few vellus follicles with no terminal hairs. The diagnosis of APL was made based upon the criteria proposed. Vitamin D-dependent rickets was ruled out as it has similar clinical presentation. Accurate diagnosis of APL is required to avoid unnecessary treatment to the patient as it is commonly misdiagnosed as alopecia universalis and treated with systemic steroids.
Authors:
Manish Bansal; Kajal Manchanda; Sachin Lamba; Ss Pandey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of trichology     Volume:  3     ISSN:  0974-9241     ISO Abbreviation:  Int J Trichology     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2012-01-06     Completed Date:  2012-02-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101534370     Medline TA:  Int J Trichology     Country:  India    
Other Details:
Languages:  eng     Pagination:  112-4     Citation Subset:  -    
Affiliation:
Departments of Dermatology and Venereology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India. manishderma@gmail.com
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