Document Detail


Atrial remodeling in varying clinical substrates within beating human hearts: Relevance to atrial fibrillation.
MedLine Citation:
PMID:  22917748     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in human beating hearts. AF initiates self-perpetuating changes in electrophysiology, structure and functional properties of the atria, a phenomenon known as atrial remodeling. Hypertension, heart failure, valvular heart disease, sleep apnea, congenital heart disease are well known risk factors for AF that contribute to the development of atrial substrate. There is some evidence that reversal of atrial remodeling is possible with correction of antecedent conditions, however the timing of the intervention or upstream therapy may be critical. This review will describe the pathophysiology of atrial remodeling as it pertains to AF. We will describe components of remodeling including changes in atrial refractoriness, conduction and atrial structure, in addition to autonomic changes and anatomic factors that predispose to remodeling. We will discuss our current understanding of the electrophysiological changes that contribute to AF persistence. We will describe nature of atrial and pulmonary vein remodeling in the context of different forms of AF, with and without predisposing risk factors. We will describe the nature of remodeling over time following therapeutic interventions such as AF ablation in order to show that it does not necessarily improve and may worsen.
Authors:
Saurabh Kumar; Andrew W Teh; Caroline Medi; Peter M Kistler; Joseph B Morton; Jonathan M Kalman
Related Documents :
22276128 - Coding, recording and incidence of different forms of coronary heart disease in primary...
18665118 - Histological changes in a model of chronic heart failure induced by multiple sequential...
22290338 - Statins and coronary artery disease:clinical evidence and future perspective.
22495138 - Blood pressure and other determinants of new-onset atrial fibrillation in patients at h...
6683548 - Cardiovascular responses to increasing plasma concentrations of aq-a 39 cl, a new compo...
3375938 - Intravenous streptokinase in acute myocardial infarction.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-16
Journal Detail:
Title:  Progress in biophysics and molecular biology     Volume:  -     ISSN:  1873-1732     ISO Abbreviation:  Prog. Biophys. Mol. Biol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401233     Medline TA:  Prog Biophys Mol Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Crown Copyright © 2012. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Department of Cardiology, The Royal Melbourne Hospital, Parkville, Australia; Department of Medicine, University of Melbourne, Parkville, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Toward better understanding of powder avalanching and shear cell parameters of drug-excipient blends...
Next Document:  Explaining suicide: Identifying common themes and diverse perspectives in an urban Mumbai slum.